California Institute of Technology

Children's Hospital of Los Angeles

Ohmx Corporation

University of Southern California

Bayer Corporation

Harry B Gray

Robert H Grubbs

Thomas J Meade

Carl M Blumenfeld

Paul A Bertin

Michael J Ahrens

Karn Sorasaenee

Melanie A Yen

Joshua Palmer

Mark Salman Humayun

Mark Edward Thompson

Nathan S Lewis

Zeev Gross

Dennis A Dougherty

Dimitra Georganopoulou

Kent R Mann

Robert H Chow

Lionel E Cheruzel

Markus Franz Wunder

Mark W Grinstaff

Amitava Gupta

Alan Rembaum

Simon Christopher Jones

Jonathan James Wilker

Ivan Julian Dmochowski

Shannon W Boettcher

Jay A Labinger

Melvin I Simon

Mark S Humayun

Toshihiko Takeuchi

Brendon McNicholas

Emily L Warren

Brian R Crane

Bryan M Hunter

James R McKone

George R Rossman

Jay R Winkler

Alexander Robert Dunn

Emmanuelle Despagnet-Ayoub

Ofer Blum

Danh Ngo

Yu-Ling Hsiao

Angelique Y Louie

Claude C Frazier

Bruce Brunschwig

Matthew J Bierman

Amanda Eckermann

Erin Lamb

Aspects disclosed herein include a system for generating singlet oxygen in a gas, the system comprising: a substrate; and hexanuclear clusters operably immobilized on at least a portion of the substrate; wherein each hexanuclear cluster comprises a photosensitive octahedral core complex characterized by formula FX1a: MX(FX1a); wherein each M is independently Mo, W, or Re; wherein each X is independently a halide anion ligand; wherein the clusters are exposed to the gas and the gas comprises Ogas; wherein the clusters are exposed to a light; and wherein each hexanuclear cluster is a photosensitizer configured to generate the gaseous singlet oxygen when irradiated by the light in the presence of the Ogas.

Photocatalytic generation of singlet oxygen for air purification

Processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product may include: contacting a water oxidation electrocatalyst with the hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to the water oxidation electrocatalyst, thereby generating the oxidized hydrocarbon product; and wherein the water oxidation electrocatalyst comprises one or more transition metals other than Ru. Optionally, the water is provided in the non-aqueous solvent at a concentration less than or equal to 0.5 vol. %. Optionally, the magnitude of the anodic bias is selected to generate the oxidized hydrocarbon product characterized by selected product distribution.

Hydrocarbon oxidation by water oxidation electrocatalysts in non-aqueous solvents

In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex. The one or more first ligands independently may comprise a Lewis basic functional group and each of said one or more second ligands independently may comprise a Lewis acidic functional group.

High performance inorganic complexes for next-generation redox flow batteries

Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A 'patch' or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using same

Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using the same

The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R, R, R, and Rare independently &#x2014;F or &#x2014;N(H)&#x2014;(CH)&#x2014;Y, provided that at least one of R, R, R, and Ris &#x2014;N(H)&#x2014;(CH)&#x2014;Y, and m and Y are described herein.

Derivatized corroles and metallocorroles and their use as imaging and therapeutic agents

The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II: 

Sulfonic esters of metal oxides and methods of their use

The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II: 

Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications. 

Metallocorroles

The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.

Chemistry used in biosensors

A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or nickel-molybdenum coated on the material.

Nickel-based electrocatalytic photoelectrodes

The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, &#x3bb;, of an electron transfer process.

Electrochemical assay for the detection of enzymes

The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, &#x3bb;, of an electron transfer process.

Growing community of inventors

Pasadena, CA, United States of America

Harry B Gray