Purdue Research Foundation

Haroon Taj Mohammad

Mohamed Seleem

Mingji Dai

Dexter Cameron Davis

Herman O Sintim

Clement Opoku-Temeng

George Naclerio

Kwaku Kyei-Baffour

The present invention generally relates to compounds as a new antibiotic to treat various infections, including infections caused by methicillin-resistant, vancomycin-intermediate and vancomycin-resistant, vancomycin-resistantand. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.

Benzamide antibacterial agents

The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of

Aryl isonitriles as a new class of antimicrobial compounds

Invasive fungal infections present a formidable global public health challenge due to the limited number of approved antifungal agents and the emergence of resistance to the frontline treatment options, such as fluconazole. Three fungal pathogens of significant concern are, andgiven their propensity to cause opportunistic infections in immunocompromised individuals. This disclosure provides a set of aryl isonitrile compounds that possess broad-spectrum antifungal activity primarily against species ofand. The most potent derivatives are capable of inhibiting growth of these key pathogens at concentrations as low as 0.5 &#x3bc;M. Remarkably, the most active compounds exhibit an excellent safety profile and are non-toxic to mammalian cells even at concentrations up to 256 &#x3bc;M.

Aryl isonitrile compounds as a new class of potent, broad-spectrum antifungal compounds

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West Lafayette, IN, United States of America

Haroon Taj Mohammad