Advance Biofactures of Curacao, N.v.

Harold Stern

David Yee

This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with other pharmaceutically active materials.

High dosage topical forms of collagenase

This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with othr pharmaceutically active materials.

High concentrations of collagenase as active ingredient in non-aqueous topical pharmaceutical formulations.

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Baldwin Harbor, NY, United States of America

Harold Stern