University of Texas System

Roche Nimblegen, Inc.

Other

Science Applications International Corporation

Lynntech, Inc.

Harold R Garner

Ali E Dabiri

Michael L Huebschman

Elliot A Rudell

Alan J Cisar

Joseph S Cernansky

John Dorrance Minna

Richard O Gale

Anthony J Ragucci

John W Fondon, Iii

Jonathan D Wren

Roger A Schultz

Bala Nagendra Raja Munjuluri

Amit Kulkarni

An apparatus and method for catalyzing a reaction on a substrate () comprising, a light source (), a micromirror () positioned to redirect light () from the light source () toward a substrate () wherein the redirected light () catalyzes a chemical reaction proximate a substrate (), is disclosed. A computer () is connected to, and controls, the positioning of mirrors within the micromirror () to specifically redirect light to specific portions of a substrate. The substrate () can be placed in a reaction chamber (), wherein the light () that is redirected by the micromirror () catalyzes a chemical reaction proximate a substrate ().

Digital optical chemistry micromirror imager

An apparatus and method for catalyzing a reaction on a substrate () comprising, a light source (), a micromirror () positioned to redirect light () from the light source () toward a substrate () wherein the redirected light () catalyzes a chemical reaction proximate a substrate (), is disclosed. A computer () is connected to; and controls, the positioning of mirrors within the micromirror () to specifically redirect light to specific portions of a substrate. The substrate () can be placed in a reaction chamber (), wherein the light () that is redirected by the micromirror () catalyzes a chemical reaction proximate a substrate ().

Substrate patterning using a digital optical chemistry micromirror imager

A method, computer program product and system for analyzing multispectral images from a plurality of regions of birefringent material, such as a polymer film, using polarized light and a corresponding polar analyzer to identify differential strain in the birefringent material. For example, the birefringement material may be low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyvinylidene chloride, polyester, nylon, or cellophane film. Optionally, the method includes generating a real-time quantitative strain map.

Detecting strain in birefringent materials using spectral polarimetry

A projection device having a coherent light beam-generator that generates a light beam and a beam expander disposed to receive the light beam and to emit an expanded light beam. The projection device also includes a digital micro-mirror device disposed to receive a holographic transform of an original image and to display the holographic transform for illumination by the expanded light beam into a holographic light beam with a convergent or focusing lens disposed to receive and modulate the holographic light beam and a liquid crystal plate volumetric image reconstructor that receives the focused holographic light beam and emits a 3-dimensional holographic image of the original image.

Holographic projector

The invention relates to computer-based systems and methods for the design, comparison and analysis of genetic and proteomic databases. In a particular embodiment, the recited systems and methods have been implemented in a computer tool called ARROGANT. ARROGANT, in the analysis mode, is a comprehensive tool for providing annotation to large gene and protein collections. ARROGANT takes in a large collection of sequence identifiers and associates it with other information collected from many sources like sequence annotations, pathways, homology, polymorphisms, artifacts, etc. The simultaneous annotation for a large assembly of genes makes the collection of genomic/EST sequences truly informative.

Computer-based method for creating collections of sequences from a dataset of sequence identifiers corresponding to natural complex biopolymer sequences and linked to corresponding annotations

An optical correlator ( ) that uses a spatial light modulator ( ) to illuminate a pattern of on and off pixels into a length of an optical fiber ( ). The spatial light modulator ( ) is optically coupled to the length of fiber ( ) so that the illumination enters the fiber along that length. The optical fiber ( ) also carries light representing a bitstream of data. At the optical fiber, the illumination from the spatial light modulator interacts with the illumination of the optical bitstream. A detector ( ) is optically coupled to the same length of fiber ( ) and detects the resulting optical response to determine if a correlation exists.

Optical correlator using spatial light modulator illumination

An apparatus and method for regulating the behavior of an atomic, molecular or cellular target is disclosed that includes a light source positioned to redirect light from the light source toward the target site. The light source may be, e.g., a combination of a light and a micromirror array or a liquid crystal display. A computer connected to, and controlling, the light source and a variable spectrum generator is placed in the path of light produced by the light source, wherein the light that is passed through said variable spectrum generator is of one or more wavelengths of light and may be used for, e.g., microscopy or image scanning.

Variable spectrum generator system

The present invention relates to a method and apparatus for display of three-dimensional images and production of mega-channel phase-encoded optical communications. In certain embodiments, the device of the present invention allows for the creation and display of real-time, three-dimensional moving holograms. In the present invention, a computed image or virtual model of a real object is stored in a computer or dedicated digital signal processor (DSP). The stored image or model is then converted by the computer or DSP into its Fourier, or holographic, transform. The holographic transform is displayed on a light modulation device that is illuminated by a one portion of a laser emission. The remaining portion of the same laser emission is combined with the holographic transform at a plane to create a three-dimensional image.

Digital micro-mirror holographic projection

The invention provides computational methods and compositions for identifying polymorphic repeats in genes. Candidate polymorphic repeats are identified by detecting tandem repeats in a target coding sequence, scoring the repeats for polymorphic probability, and generating a dataset correlating the repeats with polymorphic probability. Actual polymorphic repeat are identified by further detecting the candidate polymorphic repeat in each of a population of different coding sequences, and determining whether the candidate polymorphic repeat is polymorphic in the population. Computationally derived polymorphic repeats are validated with phenotypic variations and these correlates are used to detect the presence or absence of such phenotypic variation in test genes. Variances at polymorphic repeats are identified by detecting in a test gene or coding region the presence or absence of variance at a disclosed unconventional polymorphic repeat.

Polymorphic repeats in human genes

An advanced imaging spectrograph system and method are provided for very high throughput identification, sequencing and/or genotyping of DNA and other molecules. The system is based on the integration of improved electrophoresis structures with an imaging spectrophotometer that records the entire emission spectra along an imaging line across a sequencing gel (or capillary array). The system includes spectral shape matching to improve dye identification allowing the use of dyes having nearly any emission spectra and allowing greater than four dye multiplexing.

Automatic sequencer/genotyper having extended spectral response

A filter-less imaging microscope and method for analyzing samples on a slide at multiple wavelengths of light comprising, a microscope ( ), a light dispersive element ( ) positioned to receive images from the microscope ( ) at multiple wavelengths, the light dispersive element ( ) producing an array of light from the image and a camera ( ) positioned to detect the light array produced by the light dispersive element ( ), wherein the camera ( ) detects the light array dispersed by the light dispersive element ( ) at multiple wavelengths, is disclosed. The camera ( ) can detect the entire spectrum of light produced by the light dispersive element ( ).

Light imaging microscope having spatially resolved images

An apparatus and method for catalyzing a reaction on a substrate (,) comprising, a light source (,), a micromirror (,) positioned to redirect light (,) from the light source (,) toward a substrate (,) wherein the redirected light (,) catalyzes a chemical reaction proximate a substrate (,), is disclosed. A computer (,) is connected to, and controls, the positioning of mirrors within the micromirror (,) to specifically redirect light to specific portions of a substrate. The substrate (,) can be placed in a reaction chamber (,), wherein the light (,) that is redirected by the micromirror (,) catalyzes a chemical reaction proximate a substrate (,).

An apparatus and method for analyzing samples on a slide comprising a slide mover positioned to hold a slide, a imaging spectrometer positioned in the path of light from the slide to split the light line into a light array, a light amplifier may be positioned between the imaging spectrometer and a camera, is disclosed. The camera can detect the entire spectrum of light produced by the imaging spectrometer.

Hyperspectral slide reader

An advanced imaging spectrograph system provides for slab-gel DNA sequencing and genotyping with high throughput sequencing. The system is based on the integration of improved electrophoresis structures with an imaging spectrophotometer that records the entire emission spectra along an imaging line across a sequencing gel (or capillary array). The system includes spectral shape matching to improve dye identification allowing the use of dyes having nearly any emission spectra and allowing greater than four dye multiplexing.

Growing community of inventors

Flower Mound, TX, United States of America

Harold R Garner