Bristol-myers Squibb Compnay

Other

Squibb & Sons, Inc.

Ryono, Denis E.

Weller, Harold N., Iii

Gordon, Eric M.

Delaney, Norma G.

Harold Norris Weller, Iii

Waldemar Ruediger

Wenjeng Li

John William Allen, Jr

Eric M Gordon

Erik A Rubin

R Michael Lawrence

Norma G Delaney

Victor W Rosso

Joseph Nolfo

A Erik Rubin

Alexander Bertok

Walter Ruediger

Denis E Ryono

The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert has an array of recesses adapted to receive a different number of reaction vessels of different sizes. The recesses are positioned such that all arrays are suitable for use with a standard automated liquid handier. The frame has fluid flow channels for regulating the temperature of the lower portions of the vessels. A temperature control module can be received over the base to regulate the temperature of the upper portions of the vessels for reflux reactions. The corner radii of the insert and frame opening cooperate to permit the insert to be received in the frame in only one orientation. The walls of the insert are inclined to facilitate removal by a friction fit tool. Each vessel receiving recess has a self-centering conical or semi-circular shaped bottom to maximize heat transfer and distribute the load uniformly. The vessels seat as close to the bottom surface of the base as possible to facilitate use with an air driven magnetic stirrer. A thin, electrically heated plate may be received between the base and the stirrer.

Parallel chemistry reactor with interchangeable vessel carrying inserts

The simultaneous synthesis of diverse organic compounds is performed in stackable modules which are moveable among nesting sites located on work station platforms. The reactor module includes a block adapted to receive an array of tube-like reactor vessels. The vessels are sized to optionally accept porus polyethelyene mircocannisters with radio frequency transmitter tags. Each vessel has a bottom port connected to an outlet tube. A valve block located below the reactor vessels simultaneously controls discharge through the outlet tubes. The valve block includes plates with aligned, relatively moveable sets of rib surfaces which act through Teflon encapsulated silicone O-ring cord sections to simultaneously close rows of outlet tubes. By first utilizing reactor vessels in one set of 48 positions, out of the possible reactor vessel positions in the reactor block, and then utilizing reactor vessels in the other set of 48 positions and shifting the relative position of the collection plate, a single reactor can be employed to discharge into all of the wells of a standard well microtiter collection plate. The apparatus can be used to perform the entire synthesis or only the final cleavage step of a radio frequency tagged synthesis.

Apparatus for synthesis of multiple organic compounds with pinch valve block

The simultaneous synthesis of diverse organic compounds is performed in stackable modules which are moveable among nesting sites located on work station platforms. The reactor module includes a heat transfer block adapted to receive an array of reactor vessels, preferrably in the form of solid phase extraction cartridges without sorbent, each with an outlet port. A plurality of valves are located below the vessels. The valves consist of rows of gang-controlled stopcocks which regulate the passage of fluids from the reactor vessel outlet ports into aligned channels, each formed by a pair of threated Leur tip adapters. The reactor module may be situated over a discharge module. The inlet openings in the discharge module accept the threaded ends of the Leur tip adapters. The discharge module may consist of a multi-well collector block or a drain block. An introduction module, which includes a pressure plate having an array of openings and a septum, may be received over the reactor module. The downwardly projecting rim defining each pressure plate opening cooperates with the septum to engage the mouth of the aligned reactor vessel to maintain a fluid tight seal.

Nestable, modular apparatus for synthesis of multiple organic compounds

The simultaneous synthesis of diverse organic compounds is performed in stackable modules which are moveable among nesting sites located on work station platform. The reactor module includes a block adapted to receive an array of tube-like reactor vessels. The vessels are sized to optionally accept porus polyethelyene microcannisters with radio frequency transmitter tags. Each vessel has a bottom port connected to an outlet tube. A valve block located below the reactor vessels simultaneously controls discharge through the outlet tubes. The valves block includes plates with aligned, relatively moveable sets of rib surfaces which act through Teflon encapsulated silicone O-ring cord sections to simultaneously close rows of outlet tubes. By first utilizing reactor vessels in one set of 48 positions, out of the possible 52 reactor vessel positions in the reactor block, and then utilizing reactor vessels in the other set of 48 positions and shifting the relative position of the collection plate, a single reactor can be employed to discharge into all of the wells of a standard 96 well microtiter collection plate. The apparatus can be used to perform the entire synthesis or only the final cleavage step of radio frequency tagged synthesis.

The simultaneous synthesis of diverse organic compounds is performed in stackable modules which are moveable among nesting sites located on work station platforms. The reactor module includes a block adapted to receive an array of tube-like reactor vessels. The vessels are sized to optionally accept porus polyethelyene mircocannisters with radio frequency transmitter tags. Each vessel has a bottom port connected to an outlet tube. A valve block located below the reactor vessels simultaneously controls discharge through the outlet tubes. The valve block includes plates with aligned, relatively moveable sets of rib surfaces which act through Teflon encapsulated silicone O-ring cord sections to simultaneously close rows of outlet tubes. By first utilizing reactor vessels in one set of 48 positions, out of the possible 52 reactor vessel positions in the reactor block, and then utilizing reactor vessels in the other set of 48 positions and shifting the relative position of the collection plate, a single reactor can be employed to discharge into all of the wells of a standard 96 well microtiter collection plate. The apparatus can be used to perform the entire synthesis or only the final cleavage step of a radio frequency tagged synthesis.

Apparatus for synthesis of multiple organic compounds with pinch valve

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Pennington, NJ, United States of America

Harold Norris Weller, Iii