Research Corporation Technologies, Inc.

Research Corporation Tech., Inc.

Texas Biotechnology Corporation

Harold L Kohn

Darrell Watson

Timothy P Kogan

Ajay A Rege

Shridhar V Andurkar

Nam Huh

Anticonvulsant enantiomeric amino acid derivatives

The present invention is directed to N-benzyl-2-amino-3-methoxypropionamide and stereoisomers the use thereof anti-convulsant and an intermediate in the preparation of other anti-convulsants.

The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.

Propionamide anticonvulsants

The present invention provides conjugates of mitomycin C or derivatives thereof and oligonucleotides. A conjugate of the present invention corresponds to formula I, below: ##STR1## where R is H, CH.sub.3, or C(O)SCH.sub.3, R' is O or NH, m is an integer from 1 to 10 and Ogn is an oligonucleotide. Pharmaceutical compositions and methods of using such conjugates to inhibit gene product expression are also provided.

Mitomycin oligonucleotide conjugates

The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: ##STR1## pharmaceutical compositions containing same and the use thereof in treating CNS disorders in animals.

The present invention relates to compounds of the formula ##STR1##

Amino acid derivative anticonvulsant

The present invention relates to compounds exhibiting central nervous system (CNS) activity which are useful in the treatment of epilepsy and other CNS disorders. The compounds of this invention have the following general formula: ##STR1## and pharmaceutically acceptable salts thereof.

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Houston, TX, United States of America

Harold L Kohn