Brookhaven Science Associates, Lcc

The United States of America As Represented by the United States Energy

Harold L Atkins

Suresh C Srivastava

George E Meinken

Leonard F Mausner

Alfred P Wolf

Richard M Lambrecht

Samuel Packer

Patrick Ralph Bradley-Moore

Jerald C Merrill

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

Therapeutic tin-117m compositions

Method for palliation of pain in human bone cancer using therapeutic

.sup.203 Pb-tris complex injected for use in the detection and localization of tumors. The lead-203 is produced from the deuteron bombardment of a thallium target and chemically separated from the thallium. The tris is added which complexes with the lead-203.

Production of .sup.203 Pb-tris-hydroxymethyl amino methane

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Setauket, NY, United States of America

Harold L Atkins