University of California

Harold G Monbouquette

Jacob J Schmidt

Miguel Garcia-Garibay

Systems and methods for specific nucleic acid (NA) sequence detection that do not rely on polymerase chain reaction (PCR) for target sequence amplification and do not require any special reagents other than a complementary sequence capture probe conjugated to spherical beads.

Apparatus and method for electrical detection of oligonucleotides through pore blockades

A method for producing, and a product having, a surface nanopattern, wherein the method comprises the steps of: obtaining a substrate with a smooth surface; acquiring a self-assembling monolayer precursor, wherein the precursor includes an inducible, usually photocatalytically, active region and a substrate attachment region; mixing a plurality of the self-assembling monolayer precursors with the substrate to produce a self-assembled monolayer having an exposed surface comprising the inducible active regions and anchored to the substrate smooth surface by the substrate attachment regions; obtaining a path-directable nanoparticle; contacting the path-directable nanoparticle with the exposed surface at an interface area; exposing the exposed surface contacted with the path-directable nanoparticle to an inducing event, usually exposure to light, thereby chemically altering the inducible active regions and producing a detectable state in the interface area on the exposed surface; and applying a force of variable magnitude and direction in the plane of the surface to the contacted path-directable nanoparticle to produce movement of the contacted nanoparticle over the exposed surface thereby extending the detectable state interface area into a detectable trace over the exposed surface to produce the nanopatterened surface.

Growing community of inventors

Santa Monica, CA, United States of America

Harold G Monbouquette