Siemens Medical Solutions USA, Inc.

Harmuth C Kolb

Joseph C Walsh

Gang Chen

Umesh B Gangadharmath

Dhanalakshmi Kasi

Eric Wang

Anna Katrin Szardenings

Anjana Sinha

Chul Yu

Changhui Liu

Michael Schaefers

Andreas Faust

Sven Hermann

Guenter Haufe

Klaus Kopka

Verena Hugenberg

Stefan Wagner

Hans-Joerg Breyholz

Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof

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Playa Del Ray, CA, United States of America

Harmuth C Kolb