Carrington Laboratories, Inc.

Harley R McDaniel

Bill H McAnalley

Robert Hunt Carpenter

Acemannan has been shown to be effective in treating a number of conditions where the principal mechanism of resolution or cure requires intervention by the patient's immune system. Acemannan has direct stimulatory effects on the immune system. Methods for treating cancer, viral diseases, respiratory and immune regulatory diseases, inflammations, infections and infestations by administering an acetylated mannan derivative, such as acemannan derived from aloe, are described. The method finds use in tissue cultures, animals and plants.

Uses of aloe products in the treatment of chronic respiratory diseases

Method for reducing symptoms associated with multiple sclerosis in an animal by administering to the animal an effective amount of an acetylated polymeric mannan derivative.

Uses of aloe products in the treatment of multiple sclerosis

Methods for the treatment of sarcoma, carcinoma and lymphoma in an animal by administering to the animal an effective amount of a polymeric acetylated mannan derivative.

Antineoplastic uses of aloe products

Methods of prevention and treatment of infections and infestations in an animal by administering to the animal an effective amount of an acetylated mannan derivative.

Uses of aloe products in the prevention and treatment of infections and

Methods of treating inflammatory diseases in an animal by administering to the animal an effective amount of a polymeric acetylated mannan derivative of aloe origin.

Uses of aloe products in the treatment of inflammatory diseases

A method for promoting wound healing involving initiating and accelerating wound repair and tissue regeneration in an animal by systemic administration of a bioactive polysaccharide derived from aloe vera plant.

Wound healing accelerated by systemic administration of polysaccharide

Uses of aloe products

Acemannan has now been discovered to be a potent inducer of Interleukin 1 (Il-1) and prostaglandin E.sub.2 (PGE.sub.2) production by human peripheral blood adherent cells in culture. Il-1 has been shown to be an important macrophage product and is associated with influencing the activity and production of T lymphocytes, fibroblasts, B lymphocytes and endothelial cells. Acemannan has no demonstrated toxicity, and acts as an adjuvant and immunoenhancer. Administration of an amount of acemannan sufficient to stimulate monocytes and macrophages not only produces Il-1 and PGE.sub.2 but also stimulates phagocytosis, increases antibody production, enhances antiviral activity in the serum and, in those patients with AIDS/ARC, produces defective HIV virus. Acemannan has been shown to affect the rate of virus production in viral vaccine master seed cultures by accelerating the rate of viral replication. In addition, acemannan is a potent adjuvant to viral vaccines in chickens. Acemannan has also shown specific antitumor activity against sarcoid tumors in horses.

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Dallas, TX, United States of America

Harley R McDaniel