Euro-celtique S.a.

Harjit Tamber

Malcolm Walden

Hassan Mohammad

Geoffrey Gerard Hayes

Derek Allan Prater

Steve Whitelock

Vincenzo Martinelli

Helen Kathleen Danagher

Hassan Mohammed

Geoff Hayes

The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.

Manufacturing of active-free granules and tablets comprising the same

The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human being.

Combination of active loaded granules with additional actives

The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder,

Extrusion

Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticizing excipient in an amount sufficient to act as plasticizer and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit&#xae; RSPO, a plasticizing excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit&#xae; RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.

Multiparticulates

A neutral poly(ethyl acrylate, methyl methacrylate) copolymer is employed as a carrier in the manufacture of pharmaceutical formulations containing an active ingredient. The formulations are preferably made by melt extrusion, and can have rubbery characteristics and can exhibit tamper resistance.

Particulates

A stool softener and enteric coated bisacodyl form of a pharmaceutical composition.

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Hitchin, United Kingdom

Harjit Tamber