International Business Machines Corporation

Agency for Science, Technology and Research

Universidad Del Pais Vasco/euskal Herriko Unibersitatea

Universidad Del París Vasco/euskal Herriko Unibertsitatea

Haritz Sardon

James L Hedrick

Yi Yan Yang

Amanda Catherine Engler

Julian M W Chan

Jeremy P K Tan

Jeannette M Garcia

Daniel Joseph Coady

Victor W L Ng

Xiyu Ke

Zhan Yuin Ong

Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.

Polycarbonates bearing aromatic N-heterocycles for drug delivery

One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.

Catalyst-free methods of forming polyurethanes from pentafluorophenyl carbonates

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Haritz Sardon