Biocon Limited

Harish Venkatraman Pai

Ramakrishnan Melarkode

Jose Enrique Montero Casimiro

Laxmi Adhikary

Pradip Nair

Dinesh Baskar

Saravanan Desan

Ankur Bhatnagar

Kriti Shukla

Sunaina Prabhu

Rasika Venkataraman

Harish Iyer

Anand Khedkar

Nitesh Dave

Nilanjan Sengupta

Sharath Kumar Mallapura Rangappa

Ramesh Subramani

Devesh Radhakrishnan

Sundaresh Shankar

Sudheer Chivukula

Ranjith Ramakrishna

Shanmugam Thandava Murthy

Sharath Kumar Rangappa

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.

Methods for controlling fucosylation levels in proteins

The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.

The invention relates to improvised pharmaceutical compositions permitting ingestion via oral delivery of proteins/peptides or their conjugates, and/or cation-insulin conjugate complexes demonstrating desirable pharmacokinetic profiles and potency in efficacy models of diabetes in dogs and humans. A preferred formulation comprises 0.01%-20% w/w of insulin, insulin compound conjugates and/or cation insulin conjugates, 10%-60% w/w of one or more fatty acid components selected from saturated or unsaturated C4-C12 fatty acids and/or salts of such fatty acids and additionally contains optimal amounts of other pharmaceutically suitable polymer excipients which permit improved solubility, dissolution rate and effective bioavailability of poorly water soluble compositions and consistent in-vivo release profiles upon scalability during manufacture. A further aspect of the invention features the process of preparing the aforesaid formulations.

Orally administrable solid pharmaceutical composition and a process thereof

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Bengaluru, India

Harish Venkatraman Pai