Northwestern University

Briteseed, LLC

Nanocytomics, LLC

Northshore University Healthsystem

Hariharan Subramanian

Amal Chaturvedi

Jonathan Gunn

Vadim Backman

Justin R Derbas

Sergey Rozhok

Hemant Kumar Roy

Shetha Shukair

Paul Le Rolland

Mart Angelo De La Cruz

Dhananjay Kunte

Jarema Czarnecki

Dhwanil Damania

Steve McPhilliamy

Michael Verleye

Nathan Ray

Anthony White

Mayank Vijayvergia

John Hart

Micah Litow

Jeremy D Rogers

Chester Henderson

Rebecca Bartel

John E Chandler

Craig White

Lusik Cherkezyan

Parvathi Viswanathan

Keith Aaron Grider

Sean Corrigan

Tomas Matusaitis

Daniel Joseph Greene

Yang Liu

Marcus Stephen Papadopoulos

Young L Kim

Paul Fehrenbacher

Jerry Czarnecki

Mirela Wohlford

Simon Spence

Kyle Wolf

Michael Goldberg

Randall Brand

Prabhakar Pradhan

A surgical system includes a shaft having a distal end and a proximal end, the proximal end including a grip, a sensor attached to the distal end of the shaft, at least one visual indicator disposed at the distal end of the shaft, and a controller coupled to the sensor and the at least one visual indicator, the controller actuating the at least one visual indicator according to a signal received from the sensor.

User interface for a system used to determine tissue or artifact characteristics

Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Automated sample deposition and staining systems and associated methods

Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.

Automated specimen deposition systems and associated methods

A system and method for compensation of angular distortions in a system utilizing light emitters and light sensors disposed on non-parallel jaws may include determining a first point at a first side of a region of interest and a second point at a second side of the region of interest, determining a linear curve including the first and second points, and utilizing the linear curve to remove the angular distortion from the region of interest between the first and second points. A system and method for compensation of angular distortions may alternatively include modeling a non-pulsatile illumination pattern according to the intensities of individual emitters, comparing the pattern according to the model against a non-pulsatile illumination pattern detected using the light sensors, and varying the intensities of the individual emitters based on the comparison until angular distortion has been removed.

Optical surgical system having light emitters and light sensors coupled to a controller configured to remove angular distortion via comparison of illumination pattern

Automated cell staining systems and methods are disclosed herein. In particular, the staining systems disclosed herein provide low-volume, automated bench top staining systems for staining biological samples contained on a cytological slide.

Automated staining system

A surgical system used to determine the presence of a vessel within a region () proximate to a working end () of a surgical instrument () includes at least one light emitter () disposed at the working end () of the surgical instrument (), and at least one light sensor () disposed at the working end () of the surgical instrument () and configured to receive light emitted from the at least one light emitter () and reflected from the region (), the at least one light sensor () adapted to generate a signal comprising a first pulsatile component and a second non-pulsatile component. The system also includes a controller () coupled to the at least one light sensor (), the controller () comprising a splitter () to separate the first pulsatile component from the second non-pulsatile component and an analyzer () to determine the presence of the vessel within the region () proximate to the working end () of the surgical instrument () based on the first pulsatile component.

System to differentiate and identify types of tissue within a region proximate to a working end of a surgical instrument

A surgical system includes at least one light emitter generating light at a first intensity and an array of light sensors including a least one row of light sensors, individual light sensors in the row of light sensors adapted to generate a signal including a non-pulsatile component. The system also includes a controller coupled to the array of light sensors, the controller including an analyzer to determine the magnitudes of the non-pulsatile components at the individual light sensors in the row of light sensors, to determine if the non-pulsatile component transitions from a higher magnitude to a lower magnitude and from a lower magnitude to a higher magnitude, and if so, to determine if the first intensity should be changed to a second intensity.

System and method for determining vessel size

A surgical system used to determine if a vessel is within a region proximate to a working end of a surgical instrument includes at least one light emitter configured to emit light of two different wavelengths. The system also includes at least one light sensor disposed opposite the at least one light emitter, the at least one light sensor configured to detect light at the two different wavelengths and to provide a signal having a pulsatile and a non-pulsatile component for each wavelength. The system further includes a controller coupled to the at least one light sensor and configured to determine and indicate if the vessel is a ureter within the region proximate to the working end of the surgical instrument based on a ratio and a symmetry of a dip in the non-pulsatile component.

System and method used to determine tissue and/or artifact characteristics

A surgical system includes a tubular shaft having a wall defining an outer surface and an inner surface disposed about an inner space, the tubular shaft having a proximal end and a distal end. The surgical system also includes at least one light emitter and at least one light sensor disposed at the distal end of the tubular shaft, and one or more leads or conductors electrically coupled to the at least one light emitter or the at least one light sensor. The one or more leads may be disposed in clearances defined by first and second jaws. Alternatively or in addition, the one or more conductors may be formed on a flexible substrate, and the flexible substrate may have a deformed state in which the substrate is disposed in the inner space.

Compact system used to determine tissue or artifact characteristics

A system and method for compensation of angular distortions in a system utilizing light emitters and light sensors disposed on non-parallel jaws may include determining a first point at a first side of a region of interest and a second point at a second side of the region of interest, determining a linear curve including the first and second points, and utilizing the linear curve to remove the angular distortion from the region of interest between the first and second points, A system and method for compensation of angular distortions may alternatively include modeling a non-pulsatile illumination pattern according to the intensities of individual emitters, comparing the pattern according to the model against a non-pulsatile illumination pattern detected using the light sensors, and varying the intensities of the individual emitters based on the comparison until angular distortion has been removed.

Optical surgical system having light sensor on its jaw and method for determining vessel size with angular distortion compensation

A surgical system used to determine a size of a vessel within a region proximate to a working end of a surgical instrument includes at least one light emitter disposed at the working end, an array of light sensors disposed opposite the at least one light emitter, the array comprising a least one row of light sensors, individual light sensors in the row adapted to generate a signal comprising a pulsatile and a non-pulsatile component, and a controller coupled to the array, the controller comprising a splitter to separate the pulsatile component from the non-pulsatile component, and an analyzer to determine the magnitudes of the pulsatile and non-pulsatile components at the individual light sensors, to determine a first peak magnitude and a second peak magnitude of the pulsatile components, and to determine a resting outer diameter of the vessel based on the first and second peak magnitudes.

System and method for determining vessel size and/or edge

Growing community of inventors

Chicago, IL, United States of America

Hariharan Subramanian