Merck Sharp + Dohme Corp.

Orchid Pharma Ltd.

Allecra Therapeutics Gmbh

Hariharan Periasamy

Gopalan Balasubramanian

Maneesh Paul-Satyaseela

Ravi P Nargund

Michael W Miller

Sheo B Singh

Shuzhi Dong

Katherine Young

Hongwu Wang

Senthilkumar Udayampalayam Palanisamy

Shridhar Narayanan

Venkatesan Parameswaran

Venkateshwarlu Jakkala

Chidambaram Venkateswaran Srinivasan

Michael Wayne Miller

Sridhar Ramanathan Iyer

Senthilnathan Manickam

Aravind Appu

Bharani Thirunavukkarasu

Prabhakar Rao Gunturu

Manjula Devi Deshkumar

Sheo Singh

Michael Miller

This invention relates to carbapenem compounds of the following formula: wherein A, Z, X, R, and Rare as described herein, as well as stereoisomers, pharmaceutically acceptable salts or N-oxides thereof, which may be useful for the treatment of bacterial infections, particularly drug-resistant bacterial infections, as well as the processes for the preparation of compounds, the pharmaceutical compositions of these compounds and their use in the treatment of bacterial infection.

Substituted carbapenems for the treatment of bacterial infections

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as &#x3b2;-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of &#x3b2;-lactamases. These compounds restore/potentiate the activities of &#x3b2;-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting &#x3b2;-lactamases. Formula (I) 

Compounds and their use

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Chennai, India

Hariharan Periasamy