The State University of New York

Health Research, Inc.

Haridas Pudavar

Paras Nath Prasad

Earl Jim Bergey

Indrajit Roy

Janet Morgan

Aliaksandr Kachynski

Andrey Kuzmin

Tymish Y Ohulchansky

Paras N Prasad

A method of local temperature measurement in a sample is provided. The method comprises the stimulation, at a location in the sample, of anti-Stokes and Stokes emission from fluorophores which are present at the location in the sample, measuring the intensities of the stimulated radiation and calculating the temperature at the location from the measured intensities. The method can be used to obtain a thermal image of the sample.

Imaging methods

The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.

Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same

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North Tonawanda, NY, United States of America

Haridas Pudavar