The General Hospital Corporation

New York University

University of Iowa Research Foundation

Hari G Garg

Robert J Linhardt

Leslie I Gold

Lunyin Yu

John W Siebert

Charles A Hales

This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative. Abnormal growth of cells refers to cell growth independent of normal regulatory mechanism (e.g. loss of contact inhibition). This includes the abnormal growth of: (1) tumor cells (tumors); (2) benign and malignant cells of other proliferative disease in which aberrant cellular proliferation occurs; (3) aberrant smooth muscle cell proliferation, such as might occur following treatment for coronary atherosclerosis such as angioplasty or the insertion of a stent into an occluded vessel.

Treatment and prevention of abnormal cellular proliferation

Hyaluronan associated proteins, in particular calreticulin, promote the accelerated and relatively scarless healing of wounds. Methods for treating wounds using such proteins, and pharmaceutical compositions comprising such proteins, are provided.

Beneficial wound healing applications of calreticulin and other

Growing community of inventors

Belmont, MA, United States of America

Hari G Garg