Korea Institute of Ocean Science & Technology

Korea Ocean Research and Development Institute

Hari Datta Bhattarai

Joung Han Yim

Il Chan Kim

Se Jong Han

Hyoung Seok Lee

Tai Kyoung Kim

Doc Kyu Kim

Dockyu Kim

Hyun Cheol Oh

Hong Kum Lee

Sung Gu Lee

Su-Geun Yang

Lee Don Hang

Keun Sik Kim

Paudel Babita

Yoo Kyung Lee

Soon Gyu Hong

There is provided a novel use of ramalin for preventing or treating liver diseases, and more specifically, a pharmaceutical composition for preventing or treating hepatic fibrosis or cirrhosis containing ramalin or a pharmaceutically acceptable salt thereof, and a functional food containing the same. It was confirmed that at the time of applying ramalin, which is a compound derived fromaccording to the present invention, to animal models, ramalin may remarkably suppress hepatic fibrosis and lower liver cirrhosis levels as compared to silymarin known as a liver cell protecting ingredient without cytotoxicity to normal liver cells, such that ramalin may be effectively used for preventing or treating hepatic fibrosis and liver cirrhosis.

Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin

Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.

Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group

The present invention relates to a novel compound having excellent antioxidant activity, isolated from, and more particularly to a novel compound, RAMALIN&#x2122;, having excellent antioxidant activity, isolated from the Antarctic lichen, a method for preparing the RAMALIN&#x2122;, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN&#x2122; as an active ingredient. The RAMALIN&#x2122; according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.

Compound ramalin and use thereof

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Incheon, South Korea

Hari Datta Bhattarai