Global Life Sciences Solutions USA LLC

General Electric Company

Ge Healthcare Bio-sciences Ab

Haresh Digambar Patil

Praveen Paul

Sebastian John

Manoj Kumar Ramakrishna

Anoop Bhargav

Manish Uddhaorao Choudhary

Pradeep R Kumar

Nivedita Phadke

Prashanth Hosabettu Mohan

Swapnil Puranik

Nagaraju Konduru

Ganesan Mariyappan

A tray configured to be provided on a base station of a bioreactor system, said tray comprising a bottom and surrounding side walls and being configured to hold a bioreactor bag, said bottom comprising at least two bottom parts, whereof one is a middle part of the bottom, wherein at least one of the bottom parts is movable into at least a first and a second position, wherein said first position provides the bottom parts substantially flush with each other providing a substantially plane bottom of the tray and said second position provides a bottom of the tray having a recessed middle part.

Bioreactor tray

Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.

Apparatus and methods for adjustable volume cell culture

The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (), each being able to hold media for use in a bioreactor a mixing unit () for creating a uniform mixing of media a first feeding mechanism (), arranged to feed media from the supply units () into the mixing unit (), a control unit () operatively connected to the first feeding mechanism () and the mixing unit (), said control unit () being configured to control the first feeding mechanism () to feed predetermined amounts of media from the plurality of supply units () to the mixing unit (), and further being configured to control the mixing unit () to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.

Mixing system

Disclosed is a biomanufacturing apparatus () comprising a housing () including top () and bottom () faces which allow stacking of plural housings, an access door () at a front side of the housing, a substantially enclosed bioreactor chamber () inside the housing accessible via the door, and a further substantially enclosed region () inside the housing containing electrical parts and/or electronic control components, the chamber () including: a tray () for supporting a bioreactor, a tray support () including a mechanism () for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.

Biomanufacturing apparatus

Disclosed is biomanufacturing apparatuscomprising a housingincluding topand bottomfaces which allow stacking of plural housings, an access doorat a front side of the housing, a substantially enclosed bioreactor chamberinside the housing accessible via the door, and a further substantially enclosed regioninside the housing containing electrical parts and/or electronic control components, the chamberincluding: a trayfor supporting a bioreactor, a tray supportincluding a mechanismfor rocking the tray in use; the tray support further including a load cell () to determine changes in the mass load on the tray.

Disclosed is biomanufacturing apparatuscomprising a housingincluding topand bottomfaces which allow stacking of plural housings, an access doorat a front side of the housing, a substantially enclosed bioreactor chamberinside the housing accessible via the door, and a further substantially enclosed regioninside the housing containing electrical parts and/or electronic control components, the chamberincluding: a trayfor supporting a bioreactor, a tray supportincluding a mechanismfor rocking the tray in use; at least a fluid handling portionof at least one fluid pump device; and at least one connectionfor connecting to a conduit and/or path for carrying fluids, gas and/or electricity.

The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.

Bioreactor system for cell cultivation

The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.

Heatseal sampling

An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.

Growing community of inventors

Bengaluru, India

Haresh Digambar Patil