Vertex Pharmaceuticals, Inc.

Hardwin O′dowd

Michael Aaron Brodney

Jingrong Cao

Jon H Come

John E Cochran

Suganthini S Nanthakumar

Haoxuan Wang

Timothy J Senter

Leslie A Dakin

Brad D Maxwell

Steven David Stone

Elena Dolgikh

Samantha Angle

Jun Myun Ahn

Jessica Howard Olsen

Akira Joseph Shimizu

The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Inhibitors of APOL1 and methods of using same

Growing community of inventors

Cambridge, MA, United States of America

Hardwin O′dowd