Boehringer Mannheim Gmbh

Other

Roche Diagnostics Gmbh

Heidelberg Pharma Ag

Harald Zilch

Dieter Herrmann

Alfred Mertens

Wolfgang Von Der Saal

Herbert Leinert

Elmar Bosies

Erwin Boehm

Hans-George Opitz

Klaus Strein

Gerd Zimmermann

Hans-Georg Opitz

Bernhard Konig

Edith Koch

Frank Seela

Hans Seidel

Frieder Bauss

Rainer Gumbiowski

Helmut Rosemeyer

Ulrike Leser

Erwin Bohm

Edgar Voss

Angelika Roling

Werner Bourgeouis

Einhard Kiegel

A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates as pharmaceutical active substance. These medicaments are useful to direct pharmacologically active substances to target cells and to enrich target cells with said substances. Also disclosed are in-vitro research systems containing this enzyme used to detect other substrates of this enzyme.

Lipid cleavage enzyme

The present invention concerns new phospholipid derivatives of nucleosides of the general formula (I) in which R represents a straight-chained or branched, saturated or unsaturated aliphatic residue with 9-14 carbon atoms which can optionally be substituted once or several times; R can represent a straight-chained or branched, saturated or unsaturated aliphatic residue with 8-12 carbon atoms which can optionally be substituted once or several times; m is 2 or 3; A can represent a methylene group or an oxygen; Nuc can be a nucleoside or a residue derived from a nucleoside derivative; and tautomers thereof and their physiologically tolerated salts of inorganic and organic acids and bases as well as pharmaceutical preparations containing these compounds.

Specific lipid conjugates to nucleoside diphosphates and their use as drugs

The present invention concerns new immunosuppressive and antiviral pharmaceutical agents using lipid alcohols of the general formulae I and II

Lipid alcohols as new immunosuppressive and antiviral drugs

Phospholipid derivatives of phosphono-carboxylic acids, the production

The present invention is directed to new phospholipid derivatives of acyclovir and ganciclovir that link a lipid moiety, which represents a substituted C3 backbone, to acyclovir or ganciclovir via phosphate or thiophosphate. The compounds are particularly suitable for the therapy of viral infections.

Liponucleotides of seco-nucleosides, their production as well as their

The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) ##STR1## wherein R.sup.1 represents an optionally substituted alkyl chain having 1-20 carbon atoms;

Lipid esters of nucleoside monophosphates and their use as

Covalent lipid-phosphono-carboxylic acid conjugates and application

Compounds of the formula I ##STR1## in which R.sub.1 and R.sub.2 represent a possibly substituted C.sub.8 -C.sub.15 -alkyl chain, n the number 0, 1 or 2 and A the residue of a nucleoside, processes for their preparation, as well as antiviral medicaments which contain these compounds.

Phospholipid derivatives of nucleosides and their use as anti-viral

Process for the production of asymmetrical phosphoric acid diesters

Liponucleotides containing an ether linkage in the 2-position and a thioether, sulfoxide, or sulfone linkage in the 3-position. The nucleoside component of said liponucleotide is AZT or 3'-deoxy-3'-fluorothymidine. These compounds exhibit antiviral activity.

Growing community of inventors

Mannheim, Germany

Harald Zilch