Basf Aktiengesellschaft

Harald Weifenbach

Hans-Juergen Teschendorf

Beatrice Rendenbach-Mueller

Gerd Steiner

Thomas Kuekenhoehner

Walter Himmele

Dieter Lenke

Fritz-Frieder Frickel

Wolfgang Rohr

Ernst Buschmann

Josef Gries

Hans P Hofmann

Ulrich Karl

Horst Kreiskott

Peter C Thieme

Karl-Heinz Geiss

Walter-Wielant Wiersdorff

Rolf Kretzschmar

Wolfgang Worstmann

Jans-Juergen Teschendorf

Arylalkoxythiocoumarins of the formula ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, hydrogen, C.sub.1 -C.sub.5 -alkyl, trifluoromethyl, phenyl or halogen, or together are a C.sub.3 -C.sub.5 -alkylene chain, and

Arylalkoxythiocoumarins, the preparation thereof and therapeutic

An alkoxycoumarin substituted by a heterocyclic radical, or the formula ##STR1## R.sup.1 and R.sup.2 independently of one another are each hydrogen, C.sub.1 -C.sub.5 -alkyl, trifluoromethyl, phenyl or halogen, or together form a C.sub.3 -C.sub.5 -alkylene chain, R.sup.3 is C.sub.1 -C.sub.5 -alkyl or halogen, n is an integer of from 0 to 3, R.sup.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl and Het is one of the following heterocyclic radicals: ##STR2##

Alkoxycoumarins substituted by a heterocyclic radical, their preparation

Arylalkoxycoumarins of the general formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, lower alkyl, phenyl or halogen, or the two radicals together form an alkylene bridge of 3 to 5 carbon atoms, R.sup.3 is lower alkyl or halogen, n is an integer of from 0 to 3, m is an integer of from 0 to 4, R.sup.4 is hydrogen or lower alkyl and Ar is a phenyl ring which is monosubstituted to trisubstituted by halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy or monosubstituted by nitro, cyano or trifluoromethyl or is a naphthyl ring, with the proviso that m is not 0 when Ar is unsubstituted phenyl, processes for their preparation, and drugs prepared therefrom.

Arylalkoxycoumarins

An alkoxycoumarin substituted by a heterocyclic radical, of the formula ##STR1## Het is one of the following heterocyclic radicals: where X is oxygen or sulfur.

A 5-phenyl-1,3,3a,4,5,9b-hexahydro-3H-benz(e)indole compound of the formula I: ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen or C.sub.1-3 alkyl in the 3a- or 4-position, R.sup.3 and R.sup.4 are each hydrogen, hydroxyl, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or trifluoromethyl, acetylamino or amino and R.sup.5 is hydrogen or C.sub.1-3 alkyl, or a salt thereof with a physiologically tolerated acid. The compounds and compositions are useful for treating depression or trating convulsions and which exhibit a sedative and tranquilizing effect when administered to a patient.

5-phenyl-1,2,3a,4,5,9b-hexahydro-3H-benz(e)indotes preparation and use

Novel 3-phenyl-2-styrylpyrrolidines of the formula I ##STR1## where R.sup.1 -R.sup.7 have defined meanings, are suitable for treating disorders.

3-phenyl-2-styrylpyrrolidines, preparation and use thereof

Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

Phenylpiperazine derivatives of hetarylphenols and hetarylanilines,

Novel carbamates derived from substituted cyclic .beta.-keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.

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Ludwigshafen, Germany

Harald Weifenbach