G.l. Pharma Gmbh

Alfred E. Tiefenbacher Gmbh & Co. Kg

Harald Wagner

Wolfgang Kroutil

Georg Gübitz

Georg Guebitz

Katrin Greimel

Martin Brandauer

Daniela Huber

Klaus Bleymaier

Doris Lechner

Christof Wachter

Heimo Winkler

Jens Flemming

Martina GSÖLL

Kerstin Bergmann

Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.

Abuse-deterrent pharmaceutical composition

Disclosed are pharmaceutical compositions comprising oxycodone and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone.

Abuse-deterrent pharmaceutical compositions

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Graz, Austria

Harald Wagner