Pari Pharma Gmbh

Insmed Incorporated

Karl Leibinger Asset Management Gmbh & Co. Kg.

Harald Schulz

Michael Hahn

Philipp Holzmann

Dominique Mutschmann

Vladimir Malinin

Walter Perkins

Brian S Miller

Xingong Li

Sven Zehnder

Dominique Seidel

Brian Miller

An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane having a first side for being in contact with the fluid and an opposite second side, the membrane having a plurality of through holes penetrating the membrane in an extension direction from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having along its extension direction a smallest diameter, a larger diameter that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, wherein the ratio of the total length of each through hole in the extension direction to the length of a respective one of said nozzle portions in the extension direction is at least 4, preferably at least 4.5 and most preferred equal to or larger than 5.

Aerosol generator

An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane () having a first side () for being in contact with the fluid and an opposite second side (), the membrane having a plurality of through holes () penetrating the membrane in an extension direction (E) from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole () having along its extension direction (E) a smallest diameter (Ds), a larger diameter (DL) that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion () defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, characterized in that the ratio of the total length of each through hole () in the extension direction to the length of a respective one of said nozzle portions () in the extension direction is at least (4), preferably at least (4.5) and most preferred equal to or larger than (5).

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, apulmonary infection, a pulmonary infection associated with bronchiectasis, or apulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

Systems for treating pulmonary infections

Growing community of inventors

Tuttlingen, Germany

Harald Schulz