Rheinische Friedrich-wilhelms-universitat Bonn

UniversitÄt Zu Koln

Life & Brain Gmbh

Rheinische Friedrich-Wilhelms-Universität

Harald Neumann

Oliver Brüstle

Martin Glas

Anahita Shahraz

Michael Peitz

Christine Klaus

Jens Kopatz

Marcus Karlstetter

Thomas Langmann

Kristin Roy

Kristian Welle

Ruslan Masgutov

The present invention relates to 6'-sialyllactose and/or pharmaceutically acceptable salts thereof for use in the treatment of a disease selected from hearing loss and hearing loss&#x2014;associated tinnitus.

6'-sialyllactose for use in the treatment of hearing loss

The present invention relates to a branched or unbranched free or glycosidically bound polysialic acid according to general formula (1) as given as follows poly-(&#x3b1;(2&#x2192;8 or 2&#x2192;9)Neu5Ac)(1) wherein Neu5Ac is N-acetylneuraminic acid, and n is an integer in the range from 14 to 26 and/or pharmaceutically acceptable salts thereof, a polysaccharide composition comprising the polysialic acid (1), and the use as a medicament, particularly in the therapeutic and/or prophylactic treatment of degenerative, demyelinating and inflammatory diseases of the central nervous system, and degenerative or inflammatory retinal diseases.

Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory  diseases

A method for obtaining human microglial precursor cells, comprising: (a) providing a cell population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors; (c) expanding and enriching microglial precursor cells in medium comprising a growth factor selected from the group consisting of insulin and insulin-like growth factors and 10 to 150 ng/ml GM-CSF; and (d) isolating microglial precursor cells comprising CD45-positive cells.

Method for obtaining human microglial precursor cells from pluripotent stem cells

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Bonn, Germany

Harald Neumann