Abbvie Deutschland Gmbh and Co Kg

Basf Aktiengesellschaft

Abbott Gmbh & Co Kg

Harald Krull

Joerg Rosenberg

Thomas Kessler

Jörg Breitenbach

Jörg Rosenberg

Christoph Schmidt

Matthias Degenhardt

Gunther Berndl

J&ouml;rg Breitenbach

Stephan Kothrade

Ulrich Reinhold

Werner Maier

Armin Lange

Jürgen Hofmann

Rainer Klenz

Hans Bührle

Joerg Breitenbach

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (), each of the shafts () carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element () which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.

Process for producing a solid dispersion of an active ingredient

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (), each of the shafts () carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element () that is derived from a screw type element (FIG.).

The present invention relates to an apparatus for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one polymeric binder. The apparatus according to the invention has at least one extruderfor continuous plastication of the formulation and at least two injection unitswhich are provided separate from one another, each of which is connected to the extruder, and through which the formulation can be injected into at least one mold. In the process according to the invention for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one binder, the active ingredient-containing formulation is continuously plasticated, the plasticated formulation is fed into an injection unit, and the formulation present in this injection unitis injected into a mold, and plasticated formulation is fed into another injection molding unit, and the formulation present in the other injection molding unitis injected into the moldor another mold.

Method of producing solid shape forms containing an active ingredient

A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.

Process for producing solid dosage forms

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Ludwigshafen, Germany

Harald Krull