Charité – Universitätsmedizin Berlin

Charite - Universitaetsmedizin Berlin

Harald Kratz

Monika Ebert

Matthias Taupitz

Susanne Wagner

Ralf Hauptmann

Eyk Schellenberger

Jörg Schnorr

Janni Breinl

Angela Ariza De Schellenberger

Nicola Stolzenburg

Ines Gemeinhardt

Janna Glaeser

Gesche Genter

Joerg Schnorr

Monika Eber

Janna GLÄSER

Janna Glaser

The invention includes a substance based on nanocrystalline maghemite having a crystal size of between 0.5 and 4 nm, which is defined by a proportion of divalent iron ions less than five percent by weight of the total iron, and the transport of sodium and simultaneously phosphate in the gastrointestinal wall from the gastrointestinal contents into the bloodstream is reduced and thus can improve the imbalance of electrolyte and water and mineral balances of patients having impaired renal function when used orally in combination with suitable pharmaceutical adjuvants.

Drug based on maghemite for simultaneous reduction of gastrointestinal sodium resorption and phosphate resorption

The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.

Nanoparticulate phosphate adsorbent on the basis of maghemite or maghemite/magnetite, production and uses thereof

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Berlin, Germany

Harald Kratz