Bayer Aktiengesellschaft

Troponwerke Gmbh & Co Kg

Troponwerke Gmbh & Co.

Baker Aktiengesellshaft

Harald Horstmann

Egbert Wehinger

Eike Moller

Karl Meng

Friedel Seuter

Jorg Traber

Karl-August Meng, Deceased

Thomas Glaser

Peter-Rudolf Seidel

Wolfgang Dompert

Teunis Schuurman

Karl Meng, Deceased

Horst Meyer

Friedrich Bossert

Stanislav Kazda

Bodo Junge

Siegfried Raddatz

Peter Stadler

Rudolf Sundermann

Oswald Lockhoff

Arend Heise

Bernward Garthoff

Karl-Heinz Boltze

Friedrich Hoffmeister

Mithat Mardin

Hans-Dieter Dell

Bernhard Pelster

Wolf-Dieter Busse

Hans-Georg Opitz

Samir Samaan

Reinhold Kraus

Bernhard Beckermann

Teunis Schuurmann

Teunis Thurman

By Matthias Meng, Legal Representative

The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.

2-pyrimidinyl-1-piperazine derivatives processes for their preparation

2-pyrimidinyl-1-piperazine derivatives

The invention relates to substituted 2-pyrimidinyl-1- piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.

2-pyrimidinyl-1-piperazine derivatives, processes for their preparation

The invention relates to combination products with a synergistic action and antidepressant activity, containing substances having antidepressant activity and compounds having antagonistic activity and belonging to the class of dihydropyridines, and to the use of the dihydropyridines in antidepressants.

New combination products having an antidepressant action

Medicament preparations contain 2-(2-hydroxyethoxy)-ethyl N-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-anthranilate and dimethyl sulphoxide.

Medicament preparations

A method of combating rheumatic diseases which comprises administering to a patient afflicted therewith an amount effective to combat such disease of a compound of the formula ##STR1## in which Z is a glycosyl radical bonded via the anomeric carbon atom,

N-glycosylated carboxylic acid derivatives as agents for combating

Acemetacin is prepared by reaction of an indometacin with tert.-butyl halogenoacetate and subsequent cleavage with sulphuric acid and/or sulphonic acid.

Process for preparing acemetacin

The invention relates to pyrazolooxazines, pyrazolothiazines and pyrazoloquinolines defined herein by Formula I. The invention also includes compositions containing said Formula I compounds and methods for the use of said compounds and compositions for their lipoxygenase-inhibiting properties. Also included in the invention are methods for the manufacture of said compounds of Formula I.

Pyrazolooxazines, pyrazolothiazines, and pryazoloquinolines and their

The invention relates to indole derivatives identified herein by Formula (I) and a method for their preparation. Also included in the invention are compositions containing said indoles and methods for their use as antiphlogistic agents.

Indole derivatives, processes for their preparation, and their use as

The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and methods for the use of said alkenoic acid amides and the compositions containing them. In addition, the invention includes the intermediate carbonyl compounds of Formula (II) and the intermediate alkenoic acids of Formula (V) as well as methods for their preparation.

New imidazoazole-alkenoic acid amide compounds, intermediate products

Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, lower alkyl or amino;

Pyrazol-5-ones

The present invention relates to certain new imidazo [2,1-b]-[1,3,4]-thiadiazole compounds, to the provision of pharmaceutical compositions containing said compounds and to the use of said compounds and compositions as antithrombotic agents and thrombolytic agents.

Imidazo[2,1-b]-[1,3,4]-thiadiazole compounds, composition and their

The invention relates to fluorine-containing 1,4-dihydropyridine compounds and method for their preparation. Also included are compositions containing said fluorine-containing 1,4-dihydropyridine compounds and the use of said compounds and compositions as agents for influencing circulation.

Fluorine-containing 1,4-dihydropyridine compounds, pharmaceutical

Growing community of inventors

Wuppertal, Germany

Harald Horstmann