Degussa Aktiengesellschaft

Evonik Degussa Gmbh

Harald Gröger

Helge Werner

Karlheinz Drauz

Hendrik Hüsken

Werner Hummel

Jürgen Eck

Katharina Landfester

Patrick Lorenz

Josef Altenbuchner

Oliver May

Harald Trauthwein

Kai Doderer

Renate Schulze

Claudia Rollmann

Kofi Abokitse

Anne Menzel

Francoise Chamouleau

Chad Hagedorn

Françoise Chamouleau

Nicolas Orologas

The present invention is directed towards an asymmetric enzymic process for preparing optically active organic compounds. The process according to the invention is carried out in what are termed miniemulsions. The invention also relates to an enzymic reaction mixture which exhibits a miniemulsion.

Enzyme reactions in miniemulsions

The invention relates to novel polypeptides which have the biological activity of an NAD- or NADP-dependent alcohol dehydrogenase. The invention furthermore relates to nucleic acids encoding said polypeptides, to nonhuman hosts or host cells and to reaction systems which may be used for preparing desired products. The polypeptides of the invention are preferably used in the preparation, starting from aldehydes or ketones, of primary and enantiomerically pure secondary alcohols which may serve as intermediates for medicaments. Alternatively, the polypeptides of the invention may also be employed in the reverse reaction, i.e. the oxidation of alcohols with the formation of aldehydes or ketones.

Alcohol dehydrogenases

The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.

Coupled cofactor-dependent enzymatic reaction systems in aqueous media

The present invention relates to processes for the preparation of enantiomerically enriched &#x3b2;-amino acids. The invention also relates to advantageous esters of &#x3b2;-amino acids of the general formula (I)and to the use thereof in the enzymatic preparation of enantiomerically enriched &#x3b2;-amino acids.

Process for the enzymatic preparation of enantiomer-enriched &#x3b2;-amino acids

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Hanau, Germany

Harald Gröger