University of Nebraska

Haoran Sun

Stephen Gregory DiMagno

Stephen G Dimagno

The present invention is directed to a method for preparing an anhydrousF-radiolabeled fluorinating agent by a nucleophilic reaction of a hydratedF-radiolabeled fluoride ion source with an unsaturated carrier compound; treating theF-radiolabeled carrier compound to produce a non-aqueous mixture of theF-radiolabeled carrier compound in a solvent; and reacting theF-radiolabeled carrier compound with a nucleophilic composition in a nucleophilic reaction to produce an anhydrousF-radiolabeled fluorinating agent. The present invention is also directed to an anhydrousF-radiolabeled fluorinating agent comprising the formula [QM](F). Additionally, the present invention is directed to anF-radiolabeled fluorinated radiopharmaceutical or anF-radiolabeled fluorinated radiotracer prepared by reacting the anhydrousF-radiolabeled fluorinating agent with a drug intermediate. The present invention is further directed to methods for treating a disease or imaging a subject using anF-radiolabeled fluorinated radiopharmaceutical or anF-radiolabeled fluorinated radiotracer.

[object Object]

Anhydrous organic fluoride salts and reagents prepared by a method comprising the nucleophilic substitution of a fluorinated aromatic or fluorinated unsaturated organic compound with a salt having the formula:[QM]Ain an inert polar, aprotic solvent; wherein M is an atom capable of supporting a formal positive charge, the n groups Q are independently varied organic moieties, n is an integer such that the [QM] carries at least one formal positive charge, x is an integer defining the number of formal positive charge(s), +, carried by the [QM], Ais an anionic nucleophile capable of substituting for F in the fluorinated compound and F represents fluorine or a radioisotope thereof.

Growing community of inventors

Lincoln, NE, United States of America

Haoran Sun