The Johns Hopkins University

Haofan Wang

Martin Gilbert Pomper

Tomas R Guilarte

Ronnie Charles Mease

Catherine Anne Foss

Il Minn

Steven D Leach

A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.

Red fluorescent aldehyde dehydrogenase (ALDH) substrate

The present invention provides analog compounds of DPA-713 which specifically bind the translocator protein (TSPO), which is upregulated in activated leukocytes, some malignant tumors and tissues involved in steroid biogenesis. These compounds are linked via a linking moiety to a variety of imaging agents, including, for example, near infra-red dyes. The compounds of the present invention are useful for both pre-clinical near-IR fluorescence imaging (NIRF) and use in optically-guided interventions including NIRF endoscopy. Methods of use in diagnosis and treatment of TSPO related disease are also provided.

Synthesis and application of novel imaging agents conjugated to DPA 713 analogs for imaging inflammation

Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.

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Rockville, MD, United States of America

Haofan Wang