Apsam Imaging Corp.

Haoda Lu

Jun Xu

Anant Madabhushi

Kazuaki Nakane

Yao Fu

Michael D Feldman

Xiangxue Wang

Chaoyang Yan

Xiangshan Fan

The degree of differentiation of a cell in tissue is precisely determined. An estimating device () includes: a binarizing section () configured to generate binarized images from an image obtained by capturing an image of tissue; a Betti number calculating section () configured to calculate, for each binarized image, (i) the number of hole-shaped regions (b) each surrounded by pixels of a first pixel value and each composed of pixels of a second pixel value, (ii) the number of connected regions each composed of the pixels of the first pixel value connected together, and (iii) a ratio (R) between (i) and (ii); a statistic calculating section () configured to calculate statistics of the calculated numbers (b, b) and ratio (R); and an estimating section () configured to feed input data including the calculated statistics to a trained estimating model to output the degree of differentiation of the cell in tissue.

Image analysis method, estimating device, estimating system, and storage medium

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Nanjing, China

Haoda Lu