Academia Sinica

Hao-Yeh Lin

Wen-Hsiung Li

Jui-Jen Chang

Chieh-Chen Huang

Yu-Ju Lin

Caroline Thia

Ming-Che Shih

Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.

Recombinant polynucleotide sequence for producing astaxanthin and uses thereof

Described herein is an engineeredcell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).

Engineered yeast for production of enzymes

Growing community of inventors

Taipei, Taiwan

Hao-Yeh Lin