Other

Rushi Biotech (Hangzhou) Co., Ltd

State Grid Corporation of China

Taizhou Power Supply Company of State Grid Zhejiang Electric Power

Hao Tan

Zheming Wang

Zhen Huang

Jian Wu

Guode Ying

Tao Zhu

Kang Wang

Yuande Zheng

Hua Xu

Ping Zhao

Zaibing Zhou

Hao Li

Xiaochun Xu

Qingchun Zhao

Xiaotong Zhu

Yiping Shen

Yutao Qiu

Ben Li

Chi Zhang

Chen Zhou

Xu Jiang

Zheng Qin

Rijun Wang

The present invention discloses a pyrrolidine derivative or its optically active isomer, or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NADexpression. The pyrrolidine derivative has pyrrolidine as a parent structure, to which pyridinylurea (or substituted pyridinylurea) is attached by an intermediate aliphatic chain, and a side arylformyl (or heterocyclylformyl) group is attached. This structure is an optimized structure of the NAMPT inhibitor FK866, in which the acrylamido group is replaced by a urea structure, to increases the water solubility of the compound. Moreover, the difficulty in synthesis is reduced accordingly, which is conducive to the subsequent industrial production.

Pyrrolidine derivative and use thereof

The present invention discloses a pyridinylcyanoguanidine derivative or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NADexpression. The pyridinylcyanoguanidine derivative has a parent structure including cyanoguanidine attached to piperazine or pyrrolidine by an intermediate aliphatic chain, to which a side arylformyl (or heterocyclylformyl) group and pyridinyl (or substituted pyridinyl) group are attached. This structure comes from the structural optimization of FK866, a high-efficiency NAMPT inhibitor. In the structure, the substituted formyl piperazine and substituted formyl pyrrolidine are the further optimizations on the basis of FK866, which strengthens the interaction with NAMPT. The introduction of cyanoguanidine structure not only further enhances the affinity with NAMPT, but also improves the disadvantage of poor water solubility of FK866, which is more conducive to the subsequent drug test.

Pyridinylcyanoguanidine derivative and use thereof

Provided is a determination method of differential protection suitable for an electricity transmission line with multi-terminal T-connection. The determination method includes: sampling and calculating all phase currents, and calculating a maximum fault component current &#x394;&#x130;in phase current amplitudes of each phase current, a differential current Iin the each phase current, a resistive current Iin the each phase current and a vector sum &#x394;&#x130;of fault component currents except &#x394;&#x130;in the phase current amplitudes of the each phase current; and comparing the maximum fault component current &#x394;&#x130;in phase current amplitudes of each phase current and a threshold setting value I, determining a value of a resistive coefficient K corresponding to the phase current amplitudes of the each phase current according to a comparison result, and performing differential determination on the differential current Iand the resistive current Iin phase current amplitudes of the each phase current according to a differential determination formula: if the differential current Iof the target phase satisfies the above differential determination formula, it is determined that a fault occurs in an area of the target phase.

Differential protection determination method

Provided are a differential protection method and system, applied to a multi-terminal T-connection transmission line. The method includes: selecting two slaves without a connection and connecting the two slaves to construct a slave group; determining a target slave and an auxiliary slave in the slave group, where a first communication path is connected along a channel one, a channel two and a channel three, and a second communication path is connected along the channel three, the channel two and the channel one; transmitting, by the target slave, two frames of messages, and acquiring a delay difference between a transceiving delay of the first communication path and a transceiving delay of the second communication path, where a first frame of messages is transmitted to the target slave via the first communication path, a second frame of messages is transmitted to the target slave via the second communication path.

Differential protection method and system

Growing community of inventors

Zhejiang, China

Hao Tan