H. Lee Moffitt Cancer Center and Research Institute, Inc.

University of South Florida

Provectus Pharmatech, Inc

Hao Liu

Amod A Sarnaik

Shari Pilon-Thomas

Mark L McLaughlin

Eric A Wachter

Mark L Greenlee

Dongfang Meng

Jamie Singer

Keqaing Li

Mark Mclaughlin

Frances Aileen Bouffard

Weiming Fan

James M Balkovec

James Dropinski

Bruno Tse

Ahmed Mamai

Disclosed are compositions and methods for ex vivo expansion of tumor infiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumor infiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.

Tumor-infiltrating lymphocytes for adoptive cell therapy

Disclosed are compositions and methods for ex vivo expansion of tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumor-infiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.

A cancer immunotherapy method is disclosed in which 'induced immune anticancer agents' are isolated after being induced in an animal host by intralesional (IL) administration of a halogenated xanthene tumor-ablative compound into a solid cancerous tumor of that host animal. A sample of the induced immune anticancer agents is removed (collected) from the tumor-bearing host, banked if desired, cultured and preferentially expanded to form an immunologically-effective enriched tumor-specific immune anticancer agent composition. That composition is reintroduced in to the host from which the predecessor induced immune anticancer agents were taken, or into another immunologically suitable host in need.

Method of ex vivo enhancement of immune cell activity for cancer immunotherapy with a small molecule ablative compound

Growing community of inventors

Tampa, FL, United States of America

Hao Liu