Chang Gung University

National Taiwan University

National Health Research Institutes

Chang Gung Memorial Hospital, Linkou

Chang Gung Memorial Hospital, Keelung

Chang Chung University

Navifus Co. Ltd.

Hao-Li Liu

Kuo-Chen Wei

Pin-Yuan Chen

Hsu Chang

Mu-Yi Hua

Rung-Ywan Tsai

Hung-Wei Yang

Wen-Shiang Chen

Shin-Yan Chiou

Wen-Pin Shih

Wen-Yen Lin

Chi-An Dai

Kun-Lung Chuang

Cheng-Keng Chuang

See-Tong Pang

Chien-Ching Ma

I-Yeh Lu

Sheng-Min Huang

Chen-Kai Jan

Yen-Tung Huang

Jing-Jing Xia

Chih-Hung Tsai

Chao-Ming Hsieh

Meng-Tsan Tsai

Hong-Chieh Tsai

Ming-Shi Lin

Yu-Jen Lu

Heng-Wun Chen

Chung-Yin Lin

Chih-Kuang Yeh

Po-Hung Hsu

Sheng-Fu Chen

Chung-Cheng Kung

Wei-Bor Tsai

Chen-Yuan Liao

Po-Chun Chu

Ting-Chia Chang

Win-li Lin

Wen-Yen Chai

Jhen-Hao Guo

Ting-Kuang Chang

Chiung-Yin Huang

Kou-Chen Wei

An operation method of an image capture device includes steps as follows. The MEMS driver is controlled through the field programmable gate array (FPGA) independently to adjust at least one micro electro mechanical system (MEMS) scanning mirror of the optical system; at least one digital signal provided by the linear image sensor module is processed through the FPGA directly so as to obtain at least one image data.

Image capture device and operation method thereof

A method includes providing medical images of a subject for selecting a target image from thereamong, building a 3D image model based on the medical images and the target image with a surgical target site assigned, performing image registration to superimpose the 3D image model on a real-time image of the subject so as to result in a combined image, determining a virtual entry site located on the combined image, connecting the surgical target site and the virtual entry site with a straight line, generating a guiding path extending from the virtual entry site, in a direction away from the surgical target site and along the straight line, and displaying the guiding path for guiding a surgical instrument.

Method, system, computer program product and application-specific integrated circuit for guiding surgical instrument

A system includes an image capturing device, a subject reference marker disposed adjacent to a subject, a tool reference marker disposed on a treatment tool, a display device mounted on an operator, an operator reference marker disposed on the display device, and a processor. The image capturing device includes two image capturing modules that simultaneously and respectively capture two images of the operator, the subject, and the treatment tool. The processor receives the images, analyzes the images to obtain spatial locations of the reference markers, and transmits coordinate information and auxiliary information.

System for facilitating medical treatment

The present invention provides imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography. The systems coordinate imaging devices, optical coherence tomography (OCT), and pulsed ultrasound (FUS) and or pulsed ultrasound (PUS) to enhance the contrast of images. Moreover, the systems improve in vivo diagnosis and drug release through the utilization of sonographic enhancers such as microbubbles (MBs).

Imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography

A display device for ultrasound energy includes a focused ultrasound emitting and receiving device, a processing device and a display. The processing device generates a first electrical signal and transmits it to the focused ultrasound emitting and receiving device to control the focused ultrasound emitting and receiving device to emit at least one first ultrasound signal to a target position of an organism. The target position reflects the first ultrasound signal to form at least one second ultrasound signal. After generating the first electrical signal, the processing device drives the focused ultrasound emitting and receiving device to start to receive the second ultrasound signal only during a preset period after the estimation period. The processing device uses the display to display an image of the target position according to the second ultrasound signal, and brightness of the image is directly proportional to energy intensity of the first ultrasound signal.

Display device for ultrasound energy

The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point.

Focused ultrasound guiding system and method thereof

Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.

Method for ultrasound-mediated delivery system to monitor molecular penetration

A processing system and a confocal processing method for confocally emitting and receiving ultrasound. Firstly, a first driving electrical signal is generated. Then, at least one first ultrasound signal having a main frequency is emitted to a reflection position according to the first driving electrical signal. With an object at the reflection position, the first ultrasound signal is reflected to form at least one second ultrasound signal. Then, a first analyzed signal whose frequency lower than the main frequency is retrieved from the second ultrasound signal, and other signals are eliminated from the second ultrasound signal, and the first analyzed signal is converted into at least one first analogous signal. Finally, first energy of a first fixed bandwidth of the first analyzed signal is retrieved by the first analogous signal. The method stops generating the first driving electrical signal when the first energy is larger than a predetermined value.

Processing system and processing method for confocally emitting and receiving ultrasound

The invention disclosed a high-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof, using the different power to burn by the same focused ultrasound transducer, and then using the apparatus to measure the temperature and elasticity estimating by the relevant analysis method.

High-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof

The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.

Magnetic nanocomposite with multi-biofunctional groups and method for fabricating the same

The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.

Magnetic nanomedicine for inhibiting/treating human prostate cancer

An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies.

Multiple-frequency ultrasonic phased array driving system

The invention discloses the Schlieren type ultrasonic wave observer system. The invention states optics interference by the ultrasonic wave sound field after perturbation the medium, and combines to make the interference penetration optical projection the image, the goal lies in the observation ordinary naked eye blind ultrasonic wave sound field distribution. Characteristic of the invention using the spectroscope and the reflector combination, as well as microcontroller precise time delay control, might formerly be limited under the 4F optical field length limit to enhance largely the field of vision the several fold.

Schlieren type ultrasonic wave observer system

A medical system and method for treating a disorder of a subject by thermal ablation, e.g., focused ultrasound thermal ablation, are provided. The method includes obtaining medical images that include at least one image of subject's chest and ribs to reconstruct a three-dimensional chest-rib distribution; and applying ultrasound waves on a target point beyond the subject's ribs by selectively activating one or more elements of an ultrasound phased array to avoid ultrasonic energy absorption or reflection by an intervening rib based on a calculation of a relationship between the three-dimensional chest-rib distribution and an acoustic emission direction.

Medical treatment using an ultrasound phased array

The invention is to a biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus. The invention comprises of a graphic user interface, digital multiple channel phase control kernel, multiple channel driving system, and impedance matching module, power feedback device, as well as the hemispherical low-frequency ultrasound phased array. The invention also serves as a good platform reference to develop a focused ultrasound system in the assisted brain drug delivery application.

Biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus

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Tao-Yuan, Taiwan

Hao-Li Liu