The Ohio State University

Hao-Chieh Chiu

Ching-Shih Chen

Dasheng Wang

Larry Schlesinger

John S Gunn

Samuel K Kulp

Larry Seth Schlesinger Schlesinger

John Spencer Gunn Gunn

A method of treating infection byin a subject by administering a pharmaceutical composition including a celecoxib derivative of formula I or a pharmaceutically acceptable salt thereof is described.The preparation of numerous celecoxib derivatives for testing as potential anti-staphylococcal agents is also described.

Anti-staphylococcal celecoxib derivatives

A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is &#x2014;CF, Ar is selected from and R is selected from  

Anti-infective agents against intracellular pathogens

A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection byin a subject are described.

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A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is &#x2014;CF, Ar is selected from and R is selected from where 

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Columbus, OH, United States of America

Hao-Chieh Chiu