Ohio University

Hao Chen

Zhixin Miao

Howard Dewald

Yun Zhang

Ning Pan

Jiwen Li

Yi Cai

Pengyuan Liu

Zongqian Yuan

A method of quantifying a target compound includes applying an oxidation/reduction potential to an electrochemical cell (); measuring an electrochemical current during the application of the oxidation/reduction potential; and ionizing and directing the target compound before and after the application of the oxidation/reduction potential to a mass spectrometer () that measures a target compound ion intensity. The method further includes determining a target compound ion intensity change due to the application of the oxidation/reduction potential and determining a total amount of the target compound in the sample using the measured electrochemical current and the target compound ion intensity change. Determining the target compound ion intensity change may comprise either comparing the target compound ion intensity before and after the electrolysis relative to a reference peak or comparing the integrated peak area of a target compound ion in an extracted ion chromatogram before and after the electrolysis.

Method and device for chemical quantification using electrochemical mass spectrometry without the use of standard target compounds

A mass spectrometry-based method of directly online detecting fuel cell reaction products includes passing a reactant sample () through a fuel cell () to form reaction products that exit the fuel cell () in an output stream (). The method also includes adding a derivatizing reagent () to the output stream () to form a derivatized output stream (), wherein the derivatizing reagent () reacts with a potential reaction product to thereby form a derivatized reaction product if the potential reaction product is present. The method further includes directing a charged solvent () toward the derivatized output stream () to thereby ionize the derivatized output stream () and directing the ionized, derivatized output stream () to a mass spectrometer (), the mass spectrometer () being configured to detect the derivatized reaction product.

Online monitoring of fuel cell reactions by desorption electrospray mass spectrometry

A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent () toward a pre-acidified sample () comprising the target compound, to thereby ionize the pre-acidified sample (). The method further includes directing the ionized pre-acidified sample () to a mass spectrometer (), the mass spectrometer () being configured to identify and quantify the target compound.

Ionization of chemicals in mixture at low pH by ambient ionization/mass spectrometry

A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization () was described for the kinetic study of fast reactions. The device includes a liquid jet generator () that is configured to emit a continuous liquid jet () having a length. An ambient ionization source () is directed toward a selected variable location along the continuous liquid jet () to desorb at least a portion of the continuous liquid jet (). A mass analyzer () analyzes a mass-to-charge ratio of an ionized sample that is within the desorbed portion of the continuous liquid jet (). The acquired mass spectra reflect the reaction progress in different reaction times and, therefore, may be used to derive the reaction rate.

Microsecond time-resolved mass spectrometry

An apparatus () for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (), which defines a flow passage () and is configured to supply the liquid sample. The fluid conduit () has an outer surface and a micro-hole () through the outer surface into the flow passage (). The apparatus () also includes an ambient ionizer () configured to generate and direct a charged solvent () toward the micro-hole () at the outer surface for ionizing a portion of the liquid sample () that emerges out of the micro-hole (). The apparatus () further includes a mass spectrometer () having a sample entrance () adjacent the micro-hole () configured to analyze an ionized portion of the liquid sample ().

Versatile ambient ionization-based interface for LC/MS

An apparatus to separate and analyze components of a liquid sample include a high performance liquid chromatograph with a mass spectrometer utilizing desorption electrospray ionization. This permits separation and evaluation of different components in a liquid sample. Further, this can be combined with online derivation via reactive DESI and, further, can be used with further electrochemistry.

Coupling of liquid chromatography with mass spectrometry by liquid sample desorption electrospray ionization (DESI)

An apparatus for direct analysis of the redox products, or intermediates, of an electrochemical reaction by coupling an electrochemical cell to desorption electrospray ionization mass spectrometry.

On-line and off-line coupling of EC with DESI-MS

An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage.

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Athens, OH, United States of America

Hao Chen