Nitto-denko Corporation

Abbott Laboratories Corporation

Pfizer Corporation

Pfizer Products Inc.

Hao Bai

Kwok Yin Tsang

Wenbin Ying

Seiji Nukui

Mark W Holladay

John Gaudette

Bharat Majeti

Nan-Horng Lin

Keith Brian Ryther

Hai Wang

Haiqing Yin

Lei Yu

Yi Jin

Roger C Adami

John K Lynch

Yat Sun Or

Yun He

Michael J Dart

James P Sullivan

Ru Zhou

Simon Bailey

Dilip Ramakant Bhumralkar

Anthony Lai Ling

Mingying He

Jihong Lou

Yihong Li

Paul P Ehrlich

James T Wasicak

Stephen P Arneric

Feng C Bi

Roger Adami

Paul Stuart Humphries

Fengli Guo

William A Carroll

Philip R Kym

Robert J Altenbach

Arturo Perez-Medrano

Michael E Kort

Murali Gopalakrishnan

Jihua Liu

Peggy Huang

Henry Q Zhang

Jorge D Brioni

Li Wang

Robert J Gregg

John F Kincaid

Feng Bi

Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Fusogenic compounds for delivery of biologically active molecules

Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Ionizable compounds and compositions and uses thereof

This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

Polymer-based hydrotropes for hydrophobic drug delivery

Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

Reduction of endotoxins from polyanionic polymer conjugates

Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-&#x3b3;-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

Large scale process for preparing poly (glutamyl-glutamate) conjugates

This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.

Co-polymer conjugates

The present invention relates to a compound of formula (I):  or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of:  Ring A, ring B, ring C, R, R, R, R, R, L, n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).

Fused phenyl amido heterocyclic compounds

Potassium channel openers

3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

3-Pyridyl enantiomers and their use as analgesics

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

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San Diego, CA, United States of America

Hao Bai