Sph No. 1 Biochemical & Pharmaceutical Co., Ltd.

Hanzhi Zhang

Hao Liu

Ning Sun

Jinguo Ding

Zhenhui Huang

Wenyan Luo

Xiaofen Liu

Xingchen Bian

A polymyxin B component or salts thereof, and a preparation and application thereof. The polymyxin B component includes six &#x3b1;,&#x3b3;-diaminobutyric acids respectively at positions 1, 3-5 and 8-9, two threonine residues at positions 2 and 10, a phenylalanine residue at position 6 and a leucine residue at position 7 linked in sequence. The threonine residue at position 10 is linked to the &#x3b1;,&#x3b3;-diaminobutyric acid at position 4 by an amido bond, and the &#x3b1;,&#x3b3;-diaminobutyric acid at position 1 is linked to 6-methyloctyl-2-enoyl.

Polymyxin B component or salt thereof, and preparation and application thereof

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Shanghai, China

Hanzhi Zhang