University System of Maryland

Canon U.s.a., Inc.

Sandia Corporation

Canon U.S. Life Sciences, Inc.

Hanyoup Kim

Giuliano Scarcelli

Jitao Zhang

Antonio Fiore

Kunihiro Sakai

Kenton C Hasson

Ronald Francis Renzi

Johnathan Stuart Coursey

Shulin Zeng

George Maltezos

Kamlesh D Patel

Hongye Liang

Arvind Virmani

Mark R Claudnic

James L Van De Vreugde

Harini Shandilya

Melissa Gosse

Michael S Bartsch

Makoto Ogusu

Yoichi Murakami

Abhijit Dohale

Brian Scrivens

Jason Zsak

Yasuyuki Numajiri

Christopher Sneeder

Denis Alias

Jitao Zang

The present invention relates to sample-to-answer systems, devices, cartridges, and method of using the same for detecting the presence of microorganisms in a sample, such as bacteria.

Sample-to-answer system for microorganism detection featuring target enrichment, amplification and detection

The present invention relates to a method and system for a label-free cell analysis based on Brillouin light scattering techniques. Combined with microfluidic technologies according to the present invention, Brillouin spectroscopy constitutes a powerful tool to analyze physical properties of cells in a contactless non-disturbing manner. Specifically, subcellular mechanical information can be obtained by analyzing the Brillouin spectrum of a cell. Furthermore, a novel configuration of Brillouin spectroscopy is provided to enable simultaneous analysis of multiple points in a cell sample.

System and method of label-free cytometry based on Brillouin light scattering

The present invention relates to a method and system for identifying mechanical properties of a cell nucleus through a label-free cell analysis based on Brillouin light scattering techniques. The present application additionally provides a method and system for identifying cancerous cells based on mechanical properties of the cell nucleus.

Cell classification based on mechanical signature of nucleus

Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.

Microfluidic hubs, systems, and methods for interface fluidic modules

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Rockville, MD, United States of America

Hanyoup Kim