University of Sharjah

Hany A Omar

Taleb H Altel

Raafat A El-Awady

Srinivasulu Vunnam

Vunnam Srinivasulu

Farah Ibrahim Al-Marzooq

Imad Abu Yousef

Shifaa Abdin

Amin Majdalawieh

Amjad Ali

Cijo George Vazhappilly

Mawieh Hamad

Mohamad Hamad

A compound represented by following formula I: according to the present disclosure. The disclosed compound is useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for preparations and methods for pharmaceutical applications, for example, as anticancer agents. The compound was found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compound also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, the compound represented by Formula I targets multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.

Heterocyclic systems and pharmaceutical compositions thereof

There is provided novel anticancer and antibacterial compounds, pharmaceutically acceptable salts thereof, and processes for their preparation. The compounds have anticancer activity, which results in the reduction of tumour cell proliferation, enhances cancers cells apoptosis and regulation of iron signalling. The compounds are also particularly active against various Gram-negative and Gram-positive multidrug-resistant bacteria, such as extended-spectrum beta-lactamase (ESBL) producing and colistin-resistant, carbapenem-resistant, carbapenem-resistant, and methicillin-resistant(MRSA) including those with reduced susceptibility to many control antibiotics.

Nature-inspired anticancer and antibacterial motifs and pharmaceutical composition thereof

Growing community of inventors

Sharjah, United Arab Emirates

Hany A Omar