Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Sichuan Kelun-biotech Biopharmaceuticals Co., Ltd.

Hanwen Deng

Jingyi Wang

Lichun Wang

Qiang Tian

Jiaqiang Cai

Shuai Song

Hongmei Song

Hong Zeng

Rongrong Long

Zujian Tang

Tongtong Xue

Liang Xiao

Guoqing Zhong

Yao Liu

Xiaofan Duan

Jing Wang

Dengnian Liu

Qiang Zhang

Haitao Huang

Liping Liu

Ruibin Hu

Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.

Bioactive molecule conjugate, preparation method and use thereof

Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3&#x3b6; molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.

Cytotoxin and conjugate, uses of same and preparation method therefor

The present invention relates to a method for prophylactically treating or treating a viral disease, comprising administering to a subject in need thereof a dihydropyrimidine compound, and the viral diseases include, but are not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).

Dihydropyrimidine compound and preparation method and use thereof

The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).

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Chengdu, China

Hanwen Deng