Hoffmann-la Roche Inc.

Hansjorg Stoller

Kuno Schleich

Bernd Heiser

Hermann Stein

Klaus Viardot

Michel Lalonde

Ernst Cathrein

Hans Peter Wagner

Bruno Leuenberger

A novel process for producing powdered carotenoid preparations, in which a suspension of a carotenoid in a high-boiling oil is brought into contact with superheated steam during a maximum period of 30 seconds, and subsequently emulsified the liquified solution of said carotenoid in oil produced by said contact with superheated steam in an aqueous solution of a colloid and then spraying and drying said emulsion to a powder.

Powdered aqueous carotenoid dispersions

Inclusion complexes of the polyenes apocarotenal and lycopene in a cyclodextrin as well as their manufacture are described. The inclusion complexes are soluble in water, alcohol or water/alcohol mixtures.

Cyclodextrin-polyene inclusion complexes

A process for producing chiral enamines by isomerizing a beta, gamma unsaturated amine with a rhodium-diphosphine complex with the addition of an achiral triarylphosphine and, if desired, hydrolyzing the compound of the enamine I obtained to the corresponding aldehyde.

Isomerization

There is disclosed a novel process for the preparation of vitamin A acetate whereby .gamma.-acetoxy-tiglic aldehyde is reacted with the salt formed by the reaction of vinyl-.beta.-ionol, triphenylphosphine and an acid.

Novel vitamin A acetate process

Polyene compounds such as vitamin A acetate are prepared by reacting triarylphosphonium salts with aldehydes in a two-phase aqueous-organic solvent system.

Manufacture of polyene compounds via a Wittig reaction in a two phase

A process for isomerizing vitamin A and derivatives thereof utilizing either palladium or a palladium containing compound as a catalyst.

Isomerization process

A novel procedure for photochemical isomerization of vitamin A compounds or derivatives thereof in the absence of sensitizers is disclosed.

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Reinach, Switzerland

Hansjorg Stoller