Medimetrics Personalized Drug Delivery, Inc.

Koninklijke Philips Corporation N.v.

Medimetrics Personalized Drug Delivery B.v.

Stoco 10 Gmbh

Progenity, Inc.

Biora Therapeutics, Inc.

Hans Zou

Jeff Shimizu

Johan Frederik Dijksman

Anke Pierik

Lucian Remus Albu

Michel Gerardus Pardoel

Frits Tobi De Jongh

Judith Margreet Rensen

Ventzeslav Petrov Iordanov

Duncan J Anderson

Remus Albu

Bernardus Hendrikus Wilhelmus Hendriks

Maarten Marinus Johannes Wilhelmus Van Herpen

Marcellinus Petrus Carolus Michael Krijn

Ivar Schram

Oscar Hendrikus Willemsen

Jeffrey Arthur Shimizu

Hans Marc Bert Boeve

Bernardus H W Hendriks

Jeffrey A Shimizu

Antonius Theodorus Martinus Van Gogh

Antonius T M Van Gogh

Claude Jean-Marie Malaurie

Olaf Weiner

Klaas Kerkhop

Christoph Wanke

Judith Margaret Rensen

Yvan O J G Droinet

Ventzeslav Iordanov

Yvan OJG Droinet

Michael Gerardus Pardoel

Michel Pardoel

Ventzeslav P Iordanov

Klaas Kerkhof

Klaas Kerkhot

A drug delivery device () is provided comprising a drug reservoir () and a piston (). The drug reservoir () is provided for comprising a drug and comprises a flexible wall () and a dispensing hole () for dispensing the drug into an environment of the drug de delivery device (). The piston () is provide for pressing against the flexible wall () to compress the drug reservoir () for pushing an amount of the drug through the dispensing hole (). An adhesion interface () between a surface of the piston () and the flexible wall () prevents sliding between the surface of the piston () and the flexible wall ().

Drug delivery device with compressible drug reservoir

A system for administering a medicament includes a plurality of capsules, a capsule dispenser, and a capsule activator. Each of the capsules includes a reservoir containing a medicament and an outlet in communication with the reservoir through which the medicament exits the capsule. The capsule dispenser releasably contains the ingestible capsules and is adapted to dispense the capsules to a user in accordance with a predetermined schedule. The capsule activator activates the dispensed capsules prior to administration to the user.

Drug Delivery Capsules with external intelligence

A medicament delivery device, which comprises a driving mechanism and a housing () having a reservoir (), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (). The driving mechanism is adapted to press a piston () against the flexible wall () thereby releasing the substance from the reservoir () through an opening () in the reservoir (). This provides for a safe and reliable medicament delivery device.

Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system

An ingestible capsule () is provided for delivery of a drug, the capsule () comprises a first module () and a second module (). The first module () has at least one drug compartment () for comprising an amount of the drug. The drug compartment () is sealed by a foil () with an embedded conducting heating wire (). The second () module comprises electronics () for providing an electrical pulse to the heating wire () in order to open the drug compartment () by melting the foil (). The first module () and second module () comprise interoperable connection means () for securing the first module () to the second module () such that the heating wire () is electronically coupled to the electronics ().

Modular ingestible drug delivery capsule

The invention relates to a swallowable medication capsule capableof dispensing fluid medicine stored in a medication compartmentthrough a valveless exit hole. A vent holeenables ventilation of an actuator cavitywhich houses an actuator used for displacing a surfacewhich separates the medication cavityand the actuator cavity. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surfaceis not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.

Swallowable medication capsule

The invention relates to an electronic pill () for delivery of a medication () inside a mammal. The electronic pill () comprises a reservoir () for releasing the medication () in response to a predefined level of pressure. Furthermore a primary elastic element () is comprised for applying said predefined level of pressure to the reservoir () via a piston () upon release from the piston () of its constrained position. The piston () in its turn, when in constrained position, induces a predefined level of stress in the primary elastic element () by accordingly deforming it. The electronic pill () comprises a mechanism () for changing, upon actuation, from a constraining configuration in which the piston () is maintained at its constrained position to a releasing configuration in which the piston () is released. The mechanism () limits the displacement of the piston () during changing between said configurations to a level which is substantially smaller than the deformation introduced in the primary elastic element ().

Electronic pill for delivery of powder medication

An electronic capsule () is provided. The capsule () has a discrete drive element () comprising: a housing (), electronics for making the electronic capsule () operable, a pumping mechanism () for dosing and displacing a substance, a power source () for powering the electronic capsule () and enabling the electronics and the pumping mechanism () to operate, and a locking mechanism (); and a discrete payload element () comprising: a housing (), a reservoir () for storing the substance, one or more openings () in the housing () for releasing the substance from the reservoir () and a locking mechanism () for engaging the drive element locking mechanism (). Engagement of the drive element locking mechanism () with the payload element locking mechanism () secures the drive element () to the payload element (), thereby making the electronic capsule () operable and specific.

Medicament delivery apparatus

A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.

Miniaturized threshold sensor

A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir () having an orifice (), a conveying unit for conveying a reservoir's content () through the orifice () and an actuator arrangement for driving the conveying unit. In order to provide a reliable delivery of medication in a humid environment, the conveying unit comprises an auger () extending in the reservoir ().

Device for delivery of powder like medication in a humid environment

Electronic pill () comprising a plurality of medicine reservoirs (), each of the reservoirs comprising a discharge opening () covered by a removable cover (). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (). The actuator can for example be a spring loaded piston () breaking a foil cover when dispensing the medicament.Alternatively, the cover can be a rotatable disk () or cylinder () with an opening () which can be brought in line with the discharge opening of a reservoir under the action of the actuator.

Electronic pill comprising a plurality of medicine reservoirs

Electronic pill () comprising at least one medicine reservoir () with a solid powder or granulate medicine, a discharge opening () and an actuator responsive to control circuitry for displacing medicine from the reservoir () to the discharge opening (). The medicine comprises a dispersion of one or more active ingredients&#x2014;e.g., solids in powder or granulate form&#x2014;in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section ().

Electronic pill comprising a medicine reservoir

An ingestible electronic capsule () for introduction into the bodily lumen comprises a circuit board with at least one electronic component (). The circuit board is formed from a flex foil (), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule ().

Ingestible electronic capsule and in vivo drug delivery or diagnostic system

A medicine reservoir () is provided for use with a drug delivery device (). The medicine reservoir () is arranged for comprising a drug () and comprises a dispensing hole () for dispensing the drug () into an environment of the drug delivery device (). The medicine reservoir () further comprises a deformable plug () which plug () is removable by pressure caused by a dispensing action of the drug delivery device ().

Medicine reservoir for drug delivery device

A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means. A plurality of the nozzle dispensers of the medicament dispensing means can be positioned tangentially to a surface of the housing such that during release of a medicament, the capsule is caused to rotate and/or translate so as to discharge the medicament homogeneously onto tissue sites of interest. In addition, by using multiple nozzles and releasing medicament at high speed, this facilitates medicament absorption by the intestines in the gastrointestinal tract.

Swallowable multi-nozzle dosing device for releasing medicines in the gastrointestinal tract

An apparatus and method for electrochemical fluid analysis comprises a chamber () having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.

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Windsor, NJ, United States of America

Hans Zou