Hoechst Aktiengesellschaft

Dade Behring Marburg Gmbh

Hans Wissmann

Rolf Geiger

Volker Teetz

Guido Simons

Hansjorg Urbach

Helmut Strecker, Deceased

Hans-Jerg Kleiner

Rainer Henning

Bernward Scholkens

Wolfgang Konig

Hansjorg Kruse

Peter Molz

Gerd Schnorr

Heinz Jurgen Skrzipczyk

Reinhard Becker

Karl Seeger

Rudolf Schleyerbach

Helmut Strecker

Ernst Lindner

Henning Hachmann

Michel Peterfalvi

A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active compound being in mutual equilibrium, by

Process and test kit for determining free active compounds in biological

The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R.sup.1 denotes an organic radical, R.sup.2 and R.sup.3 are identical or different and denote hydrogen or an organic radical, and R.sup.4 and R.sup.5, together with the atoms bearing them, form a monocyclic, bicyclic or tricyclic heterocyclic ring system having 5 to 15 carbon atoms, which process comprises reacting compounds of the formula II defined in the description with compounds of the formula IV defined in the description, in the presence of phosphinic anhydrides of the formula III, where appropriate eliminating radicals which have been introduced to protect other functional groups and, where appropriate, esterifying free carboxyl groups in a manner known per se.

Process for the preparation of n octahydropenta (6) pyrrole carboxylates

The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R.sup.1 denotes an organic radical, R.sup.2 and R.sup.3 are identical or different and denote hydrogen or an organic radical, and R.sup.4 and R.sup.5, together with the atoms bearing them, form a monocyclic, bicyclic or tricyclic heterocyclic ring system having 3 to 15 carbon atoms, which process comprises reacting compounds of the formula II defined in the description with compounds of the formula III defined in the description, in the presence of alkanephosphonic anhydrides, where appropriate eliminating radicals which have been introduced to protect other functional groups and, where appropriate, esterifying free carboxyl groups in a manner known per se.

Process for the preparation of octahydropenta(b)pyrrole carboxylates

The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R.sup.1 and R.sup.2 are identical or different and denote hydrogen or iodine, and R.sup.3 denotes H or alkyl, a process for the preparation of the compounds, and their use when carrying out immunoassays.

Novel thyronine derivatives

The invention relates to new thyronine derivatives of the formula ##STR1## in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R.sup.1 and R.sup.2 are identical or different and denote iodine or hydrogen, and R.sup.3 denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.

Thyronine derivatives

What are disclosed are indole, quinoline and isoquinoline compounds of the formula ##STR1## in which n denotes 0 or 1, m denotes 1 or 2, but (n+m).ltoreq.2, A together with the bridgehead carbon atoms denotes a benzene or a cyclohexane ring, Y.sub.1 denotes hydrogen, lower alkanoyl or lower cycloalkanoyl, benzoyl nicotinoyl or a radical of the formula II, and Y.sub.2 denotes methyl, amino, lower alkanoylamino, lower cycloalkanoylamino, benzoylamino or nicotinoylamino, and salts thereof, useful as hypotensive agents, and methods for making the same.

Bicyclic .alpha.-iminocarboxylic acid compounds having hypotensive

The invention relates to compounds of the formula I ##STR1## in which n denotes 0 or 1,

N-Acyl hexahydroindole-2-carboxylic acids and anti-hypertensive use

To prepare compounds containing carboxylic acid amide groups, in particular peptides, there are reacted compounds containing a carboxy group, in the presence of dialkylphosphinic acid anhydrides with compounds containing a free amino group.

Process for the preparation of compounds containing carboxylic acid

What is disclosed is a method of making a carboxylic acid amide, including a peptide, by reacting a compound having a free amino group with a compound having a free carboxy group in the presence of an anhydride of an alkane-phosphonic acid.

Process for the preparation of carboxylic acid amides and peptides

Pharmaceutical preparations containing an L-pyroglutamic acid amide, processes for their preparation and methods of treating psychotic diseases with them.

Pharmaceutical preparations having psychotropic activity and process for

Novel peptide derivatives and a method of preparing the same are described. These compounds are useful in the diagnosis and treatment of hypertension.

Peptides having an antihypertensive effect

Novel heptapeptides having gastrin activity

The invention relates to tripeptide amides containing pyroglutamine, proline and histidine as amino acids having anti-depressive activity and a process for their manufacture.

Growing community of inventors

Bad Soden am Taunus, Germany

Hans Wissmann