U.S. Philips Corporation

Dsm N.v.

Plus Chemicals, B.v.

Hans Wijnberg

Edsko E Havinga

Ton Rene Vries

Wolter Ten Hoeve

Dagobert Michel De Leeuw

Adam R Brown

Anita Pomp

Quirinus B Broxterman

Erik Van Echten

Lumbertus A Hulshof

Knut H Chmii

Egbert Willem Meijer

Kees Pouwer

Knut H Chmil

Kornelis L Pouwer

Venetka Ivanova Kalkman-Agayn

Mieke Ivanova Sibeyn

Jose Nieuwenhuijzen

Wijnand Sjourd Faber

The invention relates to 1,3-disubstituted-3-oxopropane-1-sulfonic acids and sulfonates and enantiomerically inriched forms thereof. The invention further relates to the use of these enantiomerically inriched compounds to resolve mixtures of enantiomers, in particular mixtures of enantiomers of amino-functionalized compounds.

3-oxopropane-1-sulphonic acids and sulphonates

A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process permits the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an enantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at least one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.

Process for the separation of a mixture of enantiomers

A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared during said process, has been provided.

Process for the production of semi synthetic statins via novel intermediates

A diastereomer complex obtained via a process for the separation of enantiomers is disclosed, wherein separation can be rapidly effected such that enantiomers are obtained with high e.e. values. The process pets the separation of mixtures of enantiomers in which more than one resolving agent is used, of which at least one resolving agent is optically active, and which yields a diastereomer complex containing at least two resolving agents in optically active form. The process provides for, inter alia, a diastereomer complex having at least three compounds of which at least two compounds are resolving agents in optically active form, and at least one compound is an onantiomer in optically active form. Also provided is a diastereomer complex having at least three compounds of which at lea one compound is a resolving agent in optically active form, and at least two compounds which are enantiomers in optically active form.

The invention relates to a method of preparing thiophene-containing or furan-containing conjugated compounds such as polythiophene. The method uses a precursor compound having tetrahydrothiophene or tetrahydrofuran precursor units having arylthio or alkylthio substituents. The precursor units can be thermally converted into thiophene or furan units. Due to the presence of the precursor units the precursor compound is soluble and can, unlike the corresponding conjugated compound, be processed from solution.

Method of preparing a thiophene-containing or furan-containing conjugated compound and precursor compound and use thereof for making semiconductor device

Method of preparing a thiophene-containing or furan-containing

Polycondensation of, for example, squaric acid with a benzodihydropyrrole, benzodithiazole, neocuproine, terthienyl or an aromatic diamine gives a semiconductive alternating copolymer having a small band gap. It is alternatively possible to use croconic acid or 5,6-dihydroxy-5-cyclohexene-1,2,3,4-tetraone instead of squaric acid. An alternating copolymer of croconic acid and a methyl-substituted benzodithiazole has the following repetititve unit: ##STR1##

Electrically conductive alternating copolymer and method of preparing

The polymers are prepared by using the new intermediate product which forms a polymeric precursor, and which is converted into the desired heterocyclic polymer by ring closure.

Method of manufacturing conductive heterocyclic polymers by reacting new

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Groningen, Netherlands

Hans Wijnberg