Schering Aktiengesellschaft

Hans Wendt

Rudolf Wiechert

Henry Laurent

Klaus Annen

Helmut Hofmeister

Joachim-Friedrich Kapp

Michael Toepert

Alfred Weber

Dieter Rahtz

Mario Kennecke

Helmut Dahl

Klaus Kieslich

Henning Koch

Peter Fuchs

Wolfgang Stindl

Peter Klaus Mengel

Ernst Schottle

Erich Gerhards

Rainold Arndt

Renate Reckers

Joachim F Kapp

Klaus Mengel

Ingfried Zimmerman

Heinz Matthes

A corticoid-containing pharmaceutical preparation adapted for topical application, comprising 0.005-2% by weight of a corticoid having antiinflammatory activity, a fatty phase, an aqueous phase, an emulsifier, a preservative, and, optionally, a fragrant substance, or an additional hydrophilic or lipophilic cosmetically active ingredients, wherein the fatty phase, and the aqueous phase are present in the form of a dispersed mixture of an oil/water emulsifier and a preservative, and a water/oil emulsion containing a water/oil emulsifier, the particle size of the inner phase of the emulsions being 2-50 .mu.m.

Corticoid-containing preparation for topical application

Compounds of Formula I ##STR1## wherein the bond  is a single bond or a double bond,

Novel 6,16-dimethylcorticoids their preparation and use

6.alpha.-Methyl corticoids of formula I ##STR1## wherein  is a single bond or a double bond, R is acyloxy of up to 8 carbon atoms, and X is chlorine, hydroxy, or acyloxy of up to 8 carbon atoms, are pharamacologically effective substances.

6.alpha.-methyl corticoids, their production and use

Compounds of Formula I ##STR1## wherein the bond   is a single bond or a double bond,

Novel 6, 16-dimethylcorticoids, their preparation and use

Corticoids of the formula ##STR1## wherein X is fluorine, chlorine and

Novel corticoids, the preparation thereof and the use thereof

Novel corticoids of formula I ##STR1## wherein X is .beta.-hydroxymethylene, .beta.-fluoromethylene or carbonyl; Y is fluorine, chlorine, hydroxy, or acyloxy of 1-10 carbon atoms; and R.sub.1 is acyloxy of 1-10 carbon atoms, possess strong anti-inflammatory activity when administered topically and display only minor systemic side effects.

Novel corticoids

Corticoids of the formula ##STR1## wherein represents a single bond or a double bond;

Novel 17-substituted 11 .beta.-hydroxy steroids of the pregnane series,

Inhalants comprising at least one corticoid of the general formula ##STR1## wherein --B--A-- is CH.sub.2 --CH.sub.2 --, CH=CH-- or CCl=CH--; X is a hydrogen atom, a fluorine atom, or methyl; Y is a hydrogen atom, a fluorine atom or a chlorine atom; Z is methylene, hydroxymethylene, fluoromethylene, a chloromethylene, or carbyl; R.sub.1 is a hydrogen atom or methyl and R.sub.2 is a hydrogen atom, or R.sub.1 and R.sub.2 collectivey are isopropylidenedioxy; and R.sub.3 is hydrocarbon of 1-12 carbon atoms, are useful for the treatment of allergic diseases of the respiratory tract.

Corticoid-containing inhalants

Benzimidazoles of the formula ##STR1## wherein R.sub.1 is o-hydroxyphenyl, a p-chlorophenyl, or p-fluorophenyl, and R.sub.2 is an alkyl of 2-4 carbon atoms, and physiologically acceptable acid addition salts thereof possess topical anti-inflammatory activity.

Benzimidazole derivatives and process for the production thereof

Pregnane-21-oic acid derivatives of the formula ##STR1## wherein THE LINKAGE REPRESENTS A SINGLE BOND OR A DOUBLE BOND;

Pregnane-21-oic acid derivatives

Steroids of the formula ##SPC1## Wherein X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, .beta.-acyloxymethylene or, when Y is a hydrogen atom, also methylene; R.sub.1 is a hydrogen atom or methyl; R.sub.2 is a hydrogen atom, an alkali metal atom or optionally substituted hydrocarbon; and --A--B-- is --CH=CH--, --CCl=CH-- or when at least one of X, Y and R.sub.1 is other than a hydrogen atom, --CH.sub.2 --CH.sub.2 --, which can be produced by oxidizing a corresponding 20-hydroxy steroid or a corresponding 21-aldehyde, possess topical anti-inflammatory activity.

Growing community of inventors

Berlin, Germany

Hans Wendt