Bayer Aktiengesellschaft

Bayer Corporation

Bayar Aktiengesellschaft

Hans-Ulrich Siegmund

Herbert Hugl

Ludger Heiliger

Eberhard Kuckert

Alison J Murray

Rolf Wehrmann

Horst Berneth

Hans-Georg Lerchen

Hans J Rosenkranz

Bruno Bomer

Paul F Corey

Matthew K Musho

Karlheinz Hildenbrand

Henry Giera

Holger Ohst

Antonius Lobberding

Klaus Sommer

Michael L Bloczynski

Meinhard Rolf

Arno Becker

Dietmar Mobius

Heinrich C Schopper

Daniel Auriel

Gunther Franke

Andreas Schumacher

Boudewijn Van Lent

Dorian Immler

This application relates to isotopically labeled affinity markers of the formula (II) 

Isotopically coded affinity markers 3

The present invention describes electrochemical sensors, preferably electrochemical biosensors, in which the reference electrode and the measuring electrode are separated from one another by a porous, electrically nonconductive sheet material.

Electrochemical sensors having improved selectivity and enhanced

A variety of diazacyanine mediators that are soluble in aqueous media and which do not inhibit enzymatic activity are provided for use on the surface of a working electrode of a electrochemical biosensor for electrochemical co-enzyme regeneration. The co-enzyme, dihydronicotinamide adenine dinucleotide (NADH) or dihydronicotinamide adenine dinucleotide phosphate (NADPH), is oxidized to NAD.sup.+ OR NADP.sup.+ which is reduced by an oxidoreductase such as a dehydrogenase acting on a substrate. By applying the mediator together with NADH or NADPH to the surface of the working electrode, the voltage necessary to achieve oxidation is substantially reduced. Biosensor electrodes such as graphite electrodes may be produced-by screen printing techniques.

Electro chemical biosensor containing diazacyanine mediator for

The present invention relates to an optical solid-phase biosensor for the detection of molecules which can be labelled with a fluorescent dye for the identification of substances in solution, for which there exists a biomolecule (receptor) which specifically recognises these and is chemically bonded to the uppermost layer of one or more layers of polyions on the surface of the sensor, by measurement of the Forster transfer between another dye molecule which is bonded in one of the uppermost layers of the sensor, and the said dye molecule.

Optical solid-phase biosensor based on polyionic layers labelled with

Disclosed is an improved electrode suitable for the electrochemical regeneration of the co-enzymes NADH and NADPH. The electrode has imparted on its surface a mediator function which is a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine. Also disclosed is a method of improving the performance of a biochemical fuel cell which operates with a dehydrogenase as a catalyst and a co-enzyme as the energy-transferring redox couple which involves using the improved electrode in the fuel cell.

Mediators suitable for the electrochemical regeneration of NADH, NADPH

The present invention relates to polymer dyestuffs, i.e. polymer-bound dyestuffs, to a process for their preparation and to their use, for example as markers in analytical procedures. Polymer dyestuffs contain linkable functional groups and are water-soluble under customary conditions of analysis. The polymer portion is usually responsible for this water solubility. The dyestuffs per se are often water-insoluble.

Polymer dyestuffs and preparation and use thereof

The present invention relates to a sensor with a novel construction for a detection method of molecules labelled with fluorescent dye for detecting these dissolved substances or analytes by energy transfer with a simple fluorescence technique and increased sensitivity in the detection as well as versatile use for different tasks and the possibility of reproducible preparation of films bound to solid surfaces.

Optical biosensor and method of use

Growing community of inventors

Krefeld, Germany

Hans-Ulrich Siegmund