Sandoz Gmbh

Hans Tscherter

Michael Morris Dreyfuss

Hans Kobel

Georg Bolliger

Jean-Jacques Sanglier

Hans Hofmann

Maximilian Grassberger

Hartmut Hauth

Gerhard Emmer

Max H Schreier

Roy Ewald

Klaus Ruedi

Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 .alpha.-amino acid residues joined together by peptide bonds, particularly the compounds of formula I ##STR1## wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761). They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties.

Pipecolic acid-containing peptolides, their preparation and

Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclization of a hydroxy-undecapeptide. The cyclic peptolides have immunosuppressive, anti-inflammatory and anti-parasitic properties.

Cyclosporin peptolides having an .alpha.-hydroxycarboxylic acid at

9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.

Ergot cyclic peptide alkaloids having a venotonizing effect, useful for

The compound of formula I ##STR1## known as S 39163/F-I which is effective e.g. as an antimicrobial and against herpes viruses.

Antibiotic lactone compound

Use of thio isosteres of ergot peptide alkaloids as vasaconstrictors

9-Thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.

9'Thia-ergots

This invention provides S 31794/F-1 which is a useful anti-mycotic for combatting Candida albicans infections.

Antibiotic S 31794/F-1

This invention provides new compounds of formula I, ##STR1## wherein R is 3-pyridyl or 3-pyridyl mono- or polysubstituted BY LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLTHIO, PHENOXY, HALOGEN, HYDROXY, OR THE GROUP ##STR2## wherein each of R.sub.1 and R.sub.2 is, independently, hydrogen or lower alkyl, Useful as prolactin secretion inhibitors for the treatment of galactorrhea.

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Allschwil, Switzerland

Hans Tscherter